臨床研究 HLA-DR陰性non-M3 AMLの臨床的検討
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- Material Type
- 記事
- Author/Editor
- 森 啓酒井 広隆真田 昌 他
- Alternative Title
- Clinical study: Clinical analysis of HLA-DR-negative non-M3 AML
- Periodical title
- 臨床血液
- No. or year of volume/issue
- 48(7) 2007.7
- Volume
- 48
- Issue
- 7
- Pages
- 547~553
- Publication date of volume/issue (W3CDTF)
- 2007-07
- ISSN (Periodical Title)
- 0485-1439
- ISSN-L (Periodical Title)
- 0485-1439
- Publication (Periodical Title)
- 東京 : 「臨床血液」編集部
- Place of Publication (Country Code)
- JP
- Text Language Code
- jpn
- Subject Heading
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z19-295
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 8906287
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- The type of leukemia was defined as HLA-DR(-) non-M3-AML, when HLA antigens were detected by flow cytometry at an incidence of <20% of the blast population excluding M3-AML. Out of 109 patients with <i>de novo</i> acute myeloid leukemia, 8 patients had HLA-DR(-) non-AML-M3. According to the French-American-British criteria, 7 patients could be subdivided into 3 patients with M1, 4 patients with M2 and 1 patient with M4. The morphological features of bone marrow aspiration demonstrated no dysplasia and peroxidase stain positivity was noted in over 86% of the blast cells in all patients, the blast cells with fine granularity in 7 patients. The cytogenetic analysis revealed a normal karyotype. There was no expression marker of the blast antigens except CD13, CD14, CD33, CD34 and CD56. All of 7 patients who underwent induction therapy attained complete remission. Overall survival and disease-free survival showed no significant differences between the HLA-DR(-) non- M3-AML group and the HLA-DR(+) AML group.フローサイトメトリにより急性前骨髄球性白血病(AML-M3)を除く芽球のHLA-DR抗原発現が20%以下の<i>de novo</i>の急性骨髄性白血病をHLA-DR (-) non-AML-M3とした。AML109例に8例のHLA-DR (-) non-AML-M3がみられた。FAB分類ではM1: 3例,M2: 4例,M4: 1例である。骨髄では,全例細胞形態異常はなく,ペルオキシダーゼ染色は86%以上陽性であり,7例に芽球に微細な顆粒がみられた。CD13, CD14, CD33, CD34, CD56以外の発現マーカーはなかった。寛解導入療法の治療を行った7例は,全例complete remission (CR)に入った。overall survivalとdisease-free survivalは,HLA-DR (-) non-AML-M3群とHLA-DR (+) AML群では差はみられていない。
- DOI
- 10.11406/rinketsu.48.547
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- フローサイトメトリにより急性前骨髄球性白血病(AML-M3)を除く芽球のHLA-DR抗原発現が20%以下の<i>de novo</i>の急性骨髄性白血病をHLA-DR (-) non-AML-M3とした。AML109例に8例のHLA-DR (-) non-AML-M3がみられた。FAB分類ではM1: 3例,M2: 4例,M4: 1例である。骨髄では,全例細胞形態異常はなく,ペルオキシダーゼ染色は86%以上陽性であり,7例に芽球に微細な顆粒がみられた。CD13, CD14, CD33, CD34, CD56以外の発現マーカーはなかった。寛解導入療法の治療を行った7例は,全例complete remission (CR)に入った。overall survivalとdisease-free survivalは,HLA-DR (-) non-AML-M3群とHLA-DR (+) AML群では差はみられていない。
- DOI
- 10.11406/rinketsu.48.547
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースPubMedCiNii Articles
- Bibliographic ID (NDL)
- 8906287
- NAID
- 10019730830