Russell小体の出現を伴った皮膚原発marginal zone B－cell lymphomaの1例

• Material Type: 記事
• Title: Russell小体の出現を伴った皮膚原発marginal zone B－cell lymphomaの1例
• Author Heading: 青木 見佳子; 川名 誠司; 新井 栄一
• Publication Date: 2010
• Publication Date (W3CDTF): 2010
• Periodical title: Ｓｋｉｎ Ｃａｎｃｅｒ
• No. or year of volume/issue: 25 2
• Volume: 25
• Issue: 2
• Pages: 168-172
• Publication date of volume/issue (W3CDTF): 2010
• ISSN (Periodical Title): 09153535
• Publication (Periodical Title): The Japanese Skin Cancer Society
• Text Language Code: ja
• Subject Heading: Primary cutaneous marginal zone B-cell lymphoma; Russell body; Mott cell
• Target Audience: 一般
• DOI: 10.5227/skincancer.25.168; https://doi.org/10.5227/skincancer.25.168
• Related Material (URI): https://search.jamas.or.jp/link/ui/2011001877
• References: Russell body‐like inclusions in oral B‐lymphomas; https://cir.nii.ac.jp/crid/1360011145347010048; Russell body gastritis: Expanding the spectrum of Helicobacter pylori – Related diseases?; https://cir.nii.ac.jp/crid/1360292619031531008; Primary Cutaneous Marginal Zone B-Cell Lymphoma; https://cir.nii.ac.jp/crid/1360292619200096896; European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas; https://cir.nii.ac.jp/crid/1361418520067780096; Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum.; https://cir.nii.ac.jp/crid/1361699993408591104; Lymphoproliferative lesions of the skin; https://cir.nii.ac.jp/crid/1361981469826562944; Primary cutaneous B-cell lymphomas – Clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome; https://cir.nii.ac.jp/crid/1362262943789707008; Russell Body Gastritis: An Unusual, Tumor-like Lesion of the Gastric Mucosa; https://cir.nii.ac.jp/crid/1362825894200629376; The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment; https://cir.nii.ac.jp/crid/1363388846262089088; The applicability and prognostic value of the new TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: results on a large cohort of primary cutaneous B-cell lymphomas and comparison with the system used by the Dutch Cutaneous Lymphoma Group; https://cir.nii.ac.jp/crid/1363951795338423552; Mott cell tumor of the stomach with <i>Helicobacter pylori</i> infection; https://cir.nii.ac.jp/crid/1364233270339172096
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org; CiNii Articles
• NAID: 10027731645

• Summary, etc.: A 46-year-old Japanese man with a solitary cutanous nodule on the nose came to our attention. The lesion had first appeared 3 years before. The cutaneous lesion was an erythematous nodule, approximately 13×12mm in diameter. Histologically, there was a grenz zone in the upper dermis, and nodular and sheet-like proliferation of lymphoid cells with dense infiltration of large eosinophilic cells (- 30m<i>μ</i> in diameter) at the periphery. The lymphoid cells were positive for CD20, CD79a, bcl-2 and CD43. As the cytoplasms of the large cells were PAS-positive, diastase resistant, they were Mott cells having many Russell bodies in the cytoplasm with displaced nuclei to the periphery. The large cells were negative for CD20, and positive for IgA and <i>κ</i>-chain. The polymerase chain reaction method using DNA extracted from a paraffin section showed a rearranged band of the IgH gene. As further investigations did not demonstrate any visceral manifestations, he has been diagnosed as having primary cutaneous marginal zone B-cell lymphoma.[<i>Skin Cancer (Japan)</i> 2010 ; 25 : 168-172]; 症例；46歳男。約3年前より鼻背部に小結節が出現し，徐々に増大した。初診時，鼻背部に直径13×12mm，表面平滑，弾性硬の淡紅色結節が存在した。病理組織所見では，表皮とはgrenz zoneを形成して真皮全層および脂肪組織上層に結節状かつ融合性の稠密な細胞浸潤がみられた。浸潤細胞はCD20，CD79a，bcl－2，CD43陽性のリンパ球で二次濾胞も形成していた。この浸潤巣の辺縁部を中心に，ジアスターゼ抵抗性PAS陽性，CD20陰性の好酸性の大型細胞が多数出現しており，電顕像とあわせRussell小体を有する形質細胞様細胞と考えた。これらがIgA，<i>κ</i>鎖陽性であり，PCR法でIgH鎖の遺伝子再構成が確認されたことより，皮膚原発marginal zone B－cell lymphomaと診断した。断続的なステロイド外用で略治状態となった。Russell小体は反応性病変，悪性B細胞リンパ腫などでしばしば少数出現する。高度な出現はヘリコバクター胃炎，消化管のリンパ腫，多発性骨髄腫などで報告されているが，皮膚原発リンパ腫での高度な出現は稀である。
• DOI: 10.5227/skincancer.25.168
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp