食物アレルギーを有する0～2歳児におけるピーナッツ，クルミ，カシューナッツ感作率の検討

• Material Type: 記事
• Title: 食物アレルギーを有する0～2歳児におけるピーナッツ，クルミ，カシューナッツ感作率の検討
• Author Heading: 森田 慶紀
• Publication Date: 2024-12-20
• Publication Date (W3CDTF): 2024-12-20
• Periodical title: 日小ア誌
• No. or year of volume/issue: 38 5
• Volume: 38
• Issue: 5
• Pages: 444-452
• Publication date of volume/issue (W3CDTF): 2024-12-20
• ISSN (Periodical Title): 09142649
• ISSN-L (Periodical Title): 09142649
• Publication (Periodical Title): THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
• Text Language Code: ja
• Subject Heading: 食物アレルギー; 乳幼児; ピーナッツ; 感作; 木の実類; food allergy; infant; peanut; sensitization; tree nuts
• Target Audience: 一般
• DOI: 10.3388/jspaci.38.444; https://doi.org/10.3388/jspaci.38.444
• Related Material (URI): https://www.jstage.jst.go.jp/article/jspaci/38/5/38_444/_pdf; https://search.jamas.or.jp/link/ui/2025135398
• References: Impact of primary food allergies on the introduction of other foods amongst Canadian children and their siblings; https://cir.nii.ac.jp/crid/1360021392652558208; Elimination diet and the development of multiple tree-nut allergies; https://cir.nii.ac.jp/crid/1360021396523987584; Tree nut introduction in a peanut‐allergic child: To eat, to screen, or to avoid?; https://cir.nii.ac.jp/crid/1360300775373198464; Reactions to peanut at first introduction in infancy are associated with age ≥8 months and severity of eczema; https://cir.nii.ac.jp/crid/1360302871320972160; Early peanut introduction; https://cir.nii.ac.jp/crid/1360579929468777984; Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel; https://cir.nii.ac.jp/crid/1362262945840094208; Ana o 3–specific IgE is a predictive marker for cashew oral food challenge failure; https://cir.nii.ac.jp/crid/1363107369937483264; Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy; https://cir.nii.ac.jp/crid/1363670320883222912; ピーナッツアレルギーの臨床像とAra h 2特異的IgE抗体検査の診断的有用性に関する検討; https://cir.nii.ac.jp/crid/1390001205000683648; Japanese society of allergology 2020; https://cir.nii.ac.jp/crid/1390285300176730496; クルミアレルギー診断におけるアレルゲンコンポーネントJug r 1特異的IgE抗体測定の有用性; https://cir.nii.ac.jp/crid/1390846609790341888
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org

• Summary, etc.: <p>Background</p><p>The prevalence of peanut and tree nut allergies in Japan has increased. However, information on sensitization in high-risk infants with food allergies (FA) remains limited. Therefore, we examined the sensitization rates of peanuts, walnuts, and cashews among children aged 0-2 years with FA.</p><p>Methods</p><p>Children aged 0-2 years who had FA between January 2019 and February 2022 were included in this study. Patient background, crude antigen and component-specific IgE levels, and sensitization rates were retrospectively evaluated from medical records.</p><p>Results</p><p>Of the 237 participants, 200 were evaluated for at least one crude antigen. Peanut sensitization was observed in 50 of 190 subjects (26%), walnut sensitization in 26 of 158 subjects (16%), and cashew sensitization in 35 of 107 subjects (33%). Peanut and walnut sensitization rates increased with age. Multivariate analysis revealed that age and egg allergy were the factors involved in peanut sensitization, age at walnut sensitization, and male sex in cashew sensitization.</p><p>Conclusion</p><p>Sensitization rates to peanuts, walnuts, and cashews in children aged 0-2 years with FA are not low and should be noted in practice.</p>; <p>【目的】食物アレルギーが疑われた0～2歳児におけるピーナッツ，クルミ，カシューナッツの感作率を検討した．</p><p>【方法】2019年1月～2022年2月に食物アレルギー診療のため受診した0～2歳児を対象とした．後方視的症例集積研究として，粗抗原およびコンポーネント特異的IgE値，その感作率を診療録より評価した．</p><p>【結果】対象237名のうち200名が少なくとも1つの粗抗原の評価を行った．ピーナッツ感作を190名中50名（26%），クルミ感作を158名中26名（16%），そしてカシューナッツ感作を107名中35名（33%）に認めた．ピーナッツ，クルミの感作率は年齢が上がるにつれて増加していた．多変量解析により，ピーナッツ感作には年齢と鶏卵アレルギー，クルミ感作には年齢，カシューナッツ感作には男児が関与する因子であった．</p><p>【結語】食物アレルギーを有する0～2歳児におけるピーナッツ，クルミ，カシューナッツに対する感作率は低くなく，診療において注意する必要がある．</p>
• DOI: 10.3388/jspaci.38.444
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp