肉芽腫とはなにか？

• Material Type: 記事
• Title: 肉芽腫とはなにか？
• Author Heading: 中溝 聡
• Publication Date: 2024-12-01
• Publication Date (W3CDTF): 2024-12-01
• Periodical title: 西日皮膚
• No. or year of volume/issue: 86 6
• Volume: 86
• Issue: 6
• Pages: 558-563
• Publication date of volume/issue (W3CDTF): 2024-12-01
• ISSN (Periodical Title): 03869784
• ISSN-L (Periodical Title): 03869784
• Publication (Periodical Title): Western Division of Japanese Dermatological Association
• Text Language Code: ja
• Target Audience: 一般
• DOI: 10.2336/nishinihonhifu.86.558; https://doi.org/10.2336/nishinihonhifu.86.558
• Related Material (URI): https://www.jstage.jst.go.jp/article/nishinihonhifu/86/6/86_558/_pdf
• References: Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis; https://cir.nii.ac.jp/crid/1050298433143300096; The Formation and Function of Granulomas; https://cir.nii.ac.jp/crid/1360013173244673408; Langhans giant cells from <i>M. tuberculosis</i>‐induced human granulomas cannot mediate mycobacterial uptake; https://cir.nii.ac.jp/crid/1360021394464927872; Ultrastructural aspects of foreign body giant cells generated on different substrates; https://cir.nii.ac.jp/crid/1360021394465410816; In vivo degradation of processed dermal sheep collagen evaluated with transmission electron microscopy; https://cir.nii.ac.jp/crid/1360021395473759104; Metabolic reprogramming and macrophage polarization in granuloma formation; https://cir.nii.ac.jp/crid/1360021395474331136; Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation; https://cir.nii.ac.jp/crid/1360302868517740672; The cellular architecture of the antimicrobial response network in human leprosy granulomas; https://cir.nii.ac.jp/crid/1360302870440738304; Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres <i>in vitro</i> and <i>in vivo</i> in mouse models; https://cir.nii.ac.jp/crid/1360302871117633408; Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15; https://cir.nii.ac.jp/crid/1360302871118178304; Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction; https://cir.nii.ac.jp/crid/1360574096018826112; The role of collagen receptors Endo180 and DDR-2 in the foreign body reaction against non-crosslinked collagen and gelatin; https://cir.nii.ac.jp/crid/1360584343742104064; Postintensive Care Syndrome: Feasibly Bridging Care at a Tertiary Trauma Center; https://cir.nii.ac.jp/crid/1360584343742681984; Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib; https://cir.nii.ac.jp/crid/1360584346966120704; Macrophage fusion: are somatic and cancer cells possible partners?; https://cir.nii.ac.jp/crid/1360855568447100800; Proinflammatory Mediators Disrupt Glucose Homeostasis in Airway Surface Liquid; https://cir.nii.ac.jp/crid/1360865818709831680; The Osteoclast: Friend or Foe?; https://cir.nii.ac.jp/crid/1361699994014356864; DAP12/TREM2 Deficiency Results in Impaired Osteoclast Differentiation and Osteoporotic Features; https://cir.nii.ac.jp/crid/1361981469762299776; The Signaling Adapter Protein DAP12 Regulates Multinucleation During Osteoclast Development; https://cir.nii.ac.jp/crid/1362544420283154816; Inflammatory cytokine production by immunological and foreign body multinucleated giant cells; https://cir.nii.ac.jp/crid/1362544420839181824; TREM2-Ligand Interactions in Health and Disease; https://cir.nii.ac.jp/crid/1363388844272875648; Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface‐adherent macrophages and foreign body giant cells; https://cir.nii.ac.jp/crid/1363670319597331712; IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin; https://cir.nii.ac.jp/crid/1363670321136532480; TREM2, a DAP12-Associated Receptor, Regulates Osteoclast Differentiation and Function; https://cir.nii.ac.jp/crid/1363951793594259200; Regulation of immunity and inflammation by hypoxia in immunological niches; https://cir.nii.ac.jp/crid/1364233271278430848
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org

• Summary, etc.: <p>肉芽腫は異物，抗酸菌や真菌の感染時などに形成される生体防御機構の一つである。免疫細胞では排除できない異物や病原体をマクロファージを主体とした免疫細胞が取り囲むことにより，体から隔離する。一方，異物や病原体に対してのみ肉芽腫は誘導されるのではなく，脂質によって形成される黄色肉芽腫や未知の抗原によ...