ELISA・immunoblot法で陰性もRNA免疫沈降法で複数抗体陽性となった抗合成酵素症候群の1例

• Material Type: 記事
• Title: ELISA・immunoblot法で陰性もRNA免疫沈降法で複数抗体陽性となった抗合成酵素症候群の1例
• Author Heading: 池田 紗矢; 清水 崇宏; 足立 正; 鈴木 重明; 西野 一三; 花島 律子
• Publication Date: 2025
• Publication Date (W3CDTF): 2025
• Periodical title: 臨床神経学
• No. or year of volume/issue: 65 3
• Volume: 65
• Issue: 3
• Pages: 211-217
• Publication date of volume/issue (W3CDTF): 2025
• ISSN (Periodical Title): 0009918X
• Publication (Periodical Title): Societas Neurologica Japonica
• Text Language Code: ja
• Subject Heading: 抗ARS抗体; 抗EJ抗体; 抗Ku抗体; RNA免疫沈降法; 炎症性筋疾患; anti-ARS antibody; anti-EJ antibody; anti-Ku antibody; RNA immunoprecipitation; inflammatory myopathy
• Target Audience: 一般
• Standard No. (Other): PMID : 40010716
• DOI: 10.5692/clinicalneurol.cn-002009; https://doi.org/10.5692/clinicalneurol.cn-002009
• Related Material (URI): https://www.jstage.jst.go.jp/article/clinicalneurol/65/3/65_cn-002009/_pdf; https://search.jamas.or.jp/link/ui/2025277915
• References: Common and Distinct Clinical Features in Adult Patients with Anti-Aminoacyl-tRNA Synthetase Antibodies: Heterogeneity within the Syndrome; https://cir.nii.ac.jp/crid/1050287297251942656; Skeletal Muscle Involvement in Antisynthetase Syndrome; https://cir.nii.ac.jp/crid/1360002214312646272; Latest update on the Ro/SS-A autoantibody system; https://cir.nii.ac.jp/crid/1360011144587627264; Autoantibody profiles delineate distinct subsets of scleromyositis; https://cir.nii.ac.jp/crid/1360017285990816768; Muscle pathology of antisynthetase syndrome according to antibody subtypes; https://cir.nii.ac.jp/crid/1360021390757578624; The phenotype of myositis patients with anti-Ku autoantibodies; https://cir.nii.ac.jp/crid/1360021393314744576; The Multicenter Study of a New Assay for Simultaneous Detection of Multiple Anti-Aminoacyl-tRNA Synthetases in Myositis and Interstitial Pneumonia; https://cir.nii.ac.jp/crid/1360285712514882048; Anti-RNP antibodies delineate a subgroup of myositis: A systematic retrospective study on 46 patients; https://cir.nii.ac.jp/crid/1360286991636350592; Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort; https://cir.nii.ac.jp/crid/1360580234555729920; Pathologic Features of Anti-Ku Myositis; https://cir.nii.ac.jp/crid/1360584341838549632; Pathologic Features of Anti-Mi-2 Dermatomyositis; https://cir.nii.ac.jp/crid/1360853567468301440; Clinical Profiles and Prognosis of Patients with Distinct Antisynthetase Autoantibodies; https://cir.nii.ac.jp/crid/1360855568722843648; Clinical significance of myositis-specific autoantibody profiles in Japanese patients with polymyositis/dermatomyositis; https://cir.nii.ac.jp/crid/1360857596602907904; Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array; https://cir.nii.ac.jp/crid/1360865424766250496; AUTOANTIBODIES IN POLYMYOSITIS; https://cir.nii.ac.jp/crid/1361137044202363904; Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology; https://cir.nii.ac.jp/crid/1361418520787163776; Muscular and extramuscular features of myositis patients with anti-U1-RNP autoantibodies; https://cir.nii.ac.jp/crid/1362262944110771072; Autoimmune Myopathies: Updates on Evaluation and Treatment; https://cir.nii.ac.jp/crid/1363388843386477696; Characteristics of interstitial lung disease in SS-A positive/Jo-1 positive inflammatory myopathy patients; https://cir.nii.ac.jp/crid/1363388844482612352; 抗ARS抗体ELISAキットの信頼性と臨床応用についての検討; https://cir.nii.ac.jp/crid/1390001204651799936; 抗合成酵素ミオパチー; https://cir.nii.ac.jp/crid/1390565134843337728; A Comparison of Line Blots, Enzyme-linked Immunosorbent, and RNA-immunoprecipitation Assays of Antisynthetase Antibodies in Serum Samples from 44 Patients; https://cir.nii.ac.jp/crid/1390853879727898240
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov

• Summary, etc.: <p>68歳女性．多関節炎，発熱，筋痛，四肢近位・頸部体幹・上肢遠位の筋力低下を認めた．高CK血症より筋炎が疑われ，間質性肺炎を伴った．検査会社に依頼可能なELISA法・immunoblot法では抗アミノアシルtRNA合成酵素（aminoacyl transfer RNA synthetase: A...