Effects of Insulin-induced Hypoglycemia on Cerebrovascular Permeability in Diabetic Rats

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Effects of Insulin-induced Hypoglycemia on Cerebrovascular Permeability in Diabetic Rats

Material type: 博士論文

Author: Tanaka, Hideakiほか

Publisher: Tanaka Hideaki

Publication date: 1991-12

Material Format: Digital

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Name of awarding university/degree: 琉球大学,博士(医学)

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Note (General)：: 報告番号(甲第19号)We studied the effect of insulin-induced hypoglycemia in both normal and streptozotocin-diabetic rats with two different durations of diabe...

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琉球医学会誌．第12巻3号（1992年8月）

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Material Type: 博士論文
Title: Effects of Insulin-induced Hypoglycemia on Cerebrovascular Permeability in Diabetic Rats
Author/Editor: Tanaka, Hideaki
田中, 秀明
Author Heading: Tanaka, Hideaki
田中, 秀明
Publication, Distribution, etc.: Tanaka Hideaki
Publication Date: 1991-12
Publication Date (W3CDTF): 1991-12
Pages: none-
Degree grantor/type: 琉球大学
Date Granted: 1991-12-25
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: cerebrovascular permeability
insulin-induced hypoglycemia
streptozotocin-diabetic rats
Evans blue
alburnin tracer
Target Audience: 一般
Note (General): 報告番号(甲第19号)
We studied the effect of insulin-induced hypoglycemia in both normal and streptozotocin-diabetic rats with two different durations of diabetes : 3 months and 6 months. The study was carried out in order to investigate : (a) whether diabetes alters cerebrovascular permeability, (b) whether the alteration of cerebrovascular permeability is changed by insulin-induced hypoglycemia. and (c) the relationship between the duration of the diabetic state and blood-brain barrier permeability. Evans blue fluorescence was used as an albumin tracer. In the basal condition, diabetic rats showed a significant increase in cerebrovascular permeability compared with normal rats. Insulin-induced hypoglycemia significantly enhanced cerebrovascular permeability in both normal rats and diabetic rats. the 6-month diabetic rats demonstrated a significant increase in cerebrovascular permeability ompared with the 3-month diabetic rats. In summry, insulin-induced hypoglycemia was thus demonstrated to be associated with a significant increase of cerebrovascular permeability in diabetic rats in relation to the duration of their diabetic state. Although the clinical sigificance of the findings still remains unknown, the results suggest the possibility that a similar phenomenon might also occur in the brain of long-term diabetic patients with severe and prolonged hypoglycemia.
学位論文
Source: https://u-ryukyu.repo.nii.ac.jp/record/2007279/files/000000410228.pdf （fulltext）
https://u-ryukyu.repo.nii.ac.jp/record/2007279/files/000000410228.pdf
Access Restrictions: インターネット公開
Related Material: 琉球医学会誌．第12巻3号（1992年8月）
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 琉球大学 : 琉球大学学術リポジトリ