拡大肝切除時に網内系賦活剤の投与や脾摘の意義に関する実験的研究

Material type: 博士論文

Author: 宮良, 球一郎ほか

Publisher: 宮良球一郎

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Name of awarding university/degree: 琉球大学,博士(医学)

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Note (General)：: 報告番号(甲第54号)The purpose of this study is to evaluate the influence of increased activity of reticuloecndothelial-function by OK-432 and splenectomy on ...

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琉球医学会誌=Ryukyu Medical Journal．12巻1号（1992）

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Material Type: 博士論文
Title: 拡大肝切除時に網内系賦活剤の投与や脾摘の意義に関する実験的研究
Author/Editor: 宮良, 球一郎
Miyara, Kyuichirou
Author Heading: 宮良, 球一郎
Miyara, Kyuichirou
Publication, Distribution, etc.: 宮良球一郎
Alternative Title: Experimental study of implication of activation of reticuloendothelial function by injection of OK-432 and splenectomy on 93% hepatectomy in rats
Degree grantor/type: 琉球大学
Date Granted: 1993-04-26
Degree Type: 博士(医学)
Text Language Code: jpn
Subject Heading: 93%hepatectomy
OK-432
splenectomy
reticuloendotherial function
Target Audience: 一般
Note (General): 報告番号(甲第54号)
The purpose of this study is to evaluate the influence of increased activity of reticuloecndothelial-function by OK-432 and splenectomy on hepatic regeneration following 93% hepatectomy in rats. Wister male rats weighting 240g to 320g were randomly allocated to 4 experimental groups and subjected to the following regimen : (1) A group; 93% hepatectomy alone, (2) B group; 93% hepatectomy + splenectomy, (3) C group; OK-432 + 93% hepatectomy, (4) D group; OK-432 + 93% hepatectomy + splenectomy. Survival rates after hepatectomy, initial, 24hour, 48hour, serum endotoxin, S-GOT, S-GPT in each group were determined. The long-term (180 days following hepatectomy) survival rates was 45.5% in A group, 13.6% in B group, 6.4% in C group and 6.3% in D group. respectively and A group survival was statistically significant bellter compared with other three groups. Serum endotoxin titers prior to hepatectomy were significantly lower (0.926 pg/ml) in OK-432 treated groups than in non-treated groups (3.3 pg/ml). 24hours after hepatcctomy, A group showed marked increase titers of endotoxin with statistical significance compared with other three groups. S-GOT and S-GPT markedly elevated 24hours after hepatectomy, but returned to the normal values 48hours after hepatectomy. These results might suggest that in 93% experimental hepatectomy in rats, activation of reticuloendotherial function could be harmful in liver regeneration after hepatectomy, and lower survival rate from the long-term survival points, therefore, anothter unknown mechanism might play an important role in liver damagt after hepatectomy.
学位論文
Source: fulltext
https://u-ryukyu.repo.nii.ac.jp/record/2007281/files/000000410274.pdf
Access Restrictions: インターネット公開
Related Material: 琉球医学会誌=Ryukyu Medical Journal．12巻1号（1992）
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 琉球大学 : 琉球大学学術リポジトリ