末梢神経急性圧迫障害に対する薬物療法の有効性に関する実験的研究

Material type: 博士論文

Author: 武内, 正典ほか

Publisher: 武内正典

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Material Format: Digital

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Name of awarding university/degree: 琉球大学,博士(医学)

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Note (General)：: 報告番号(乙第39号)Steroids and nun-steroideal antiinflammatory drugs (NSAIDs) are often administered clinically for the treatment of nerve compression injury...

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日本手の外科学会雑誌．第10巻第6号（1994）

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Material Type: 博士論文
Title: 末梢神経急性圧迫障害に対する薬物療法の有効性に関する実験的研究
Author/Editor: 武内, 正典
Takeuchi, Masanori
Author Heading: 武内, 正典
Takeuchi, Masanori
Publication, Distribution, etc.: 武内正典
Alternative Title: Experimental Studies of Drug Treatment Following Acute Nerve Compression Palsy
Degree grantor/type: 琉球大学
Date Granted: 1994-03-18
Degree Type: 博士(医学)
Text Language Code: jpn
Subject Heading: steroids
non steroideal antiinflammatory drugs (NSAIDs)
peripheral nerve
acute compression injury
Sciatic Functional Index (SFI)
Target Audience: 一般
Note (General): 報告番号(乙第39号)
Steroids and nun-steroideal antiinflammatory drugs (NSAIDs) are often administered clinically for the treatment of nerve compression injury. The present study dealt with evaluation of the effect of steroids, NSAIDs (cyclooxygenase inhibitor) and Takeda AA-861 (lipoxygenase inhibitor) on the function, using the sciatic functional indx, histology and microcirculatiun of the rat sciatic nerves following compressin. The sciatic nerve of rats wrapped with a silicone tube with appropriate internal diameter caused a compression to the nerve. It was found that steroid therapy can prevent the functional impairment caused by compression. Silicone rubber injection into the artery of the rat sciatic nerve revealed the situation of vascular impairment. The edema occured in the epineurium was prevented by steroid administration. Following epineurectomy and application of silicone tube. this recovery was not recognized although steroid was given. NSAIDs (cyclooxygenase inhibitor) and/or Takeda AA-861 (lypoxigenase inhibitor) failed to have any benifical effect. Therefore it would be concluded that acute compression nerve palsy) is caused by ederna at epineurium and the utilization of steroid is effective to prevent dysfunction due to the extrapathway of arachidonic acid metabolism in inflammatory system.
学位論文
Source: fulltext
https://u-ryukyu.repo.nii.ac.jp/record/2007282/files/000000410477.pdf
Access Restrictions: インターネット公開
Related Material: 日本手の外科学会雑誌．第10巻第6号（1994）
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 琉球大学 : 琉球大学学術リポジトリ