Development of the 12-item questionnaire for quantitative assessment of depressive mixed state (DMX-12)

• Material Type: 博士論文
• Title: Development of the 12-item questionnaire for quantitative assessment of depressive mixed state (DMX-12)
• Author/Editor: Shinzato, Hotaka; 新里, 輔鷹
• Author Heading: Shinzato, Hotaka; 新里, 輔鷹
• Publication, Distribution, etc.: University of the Ryukyus
• Publication Date: 2019-07-15
• Publication Date (W3CDTF): 2019-07-15
• Periodical title: Neuropsychiatric Disease and Treatment
• No. or year of volume/issue: 15
• Volume: 15
• Pages: 1983-1991
• ISSN (Periodical Title): ISSN : 1176-6328; ISSN : 1178-2021
• Degree grantor/type: 琉球大学
• Date Granted: 2020-02-26
• Dissertation Number: 甲第499号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: major depressive episode; depressive mixed state; spontaneous instability; vulnerable responsiveness; disruptive emotion/behavior
• Target Audience: 一般
• Note (General): Background: Conventional categorical criteria have limitations in assessing the prevalence and severity of depressive mixed state (DMX). Thus, we have developed a new scale for screening and quantification of DMX and examined the symptomatological structure and severity of DMX in individuals with major depressive episode (MDE). Methods: Subjects were 154 patients with MDE (57 males and 97 females; age 13–83 years). Our original Japanese version of the self-administered 12-item questionnaire to assess DMX (DMX-12), together with the Quick Inventory of Depressive Symptomatology Self- Report Japanese version (QIDS-SR-J) and global assessment of functioning, were administered to each participant. The symptomatological structure of the DMX-12 was examined by exploratory factor analysis. Multiple regression analyses were used to analyze factors contributing to the DMX-12 scale. The relationships of this scale with categorical diagnoses (mixed depression by Benazzi and mixed features by DSM-5) were also investigated. Results: A three-factor model of the DMX-12 was extracted from exploratory factor analysis, namely, “spontaneous instability”, “vulnerable responsiveness”, and “disruptive emotion/behavior”. Multiple regression analyses revealed that age was negatively correlated with total DMX-12 score, while bipolarity and the QIDS-SR-J score were positively correlated. A higher score on the disruptive emotion/behavior subscale was observed in patients with mixed depression and mixed features. Conclusion: The DMX-12 seems to be useful for screening DMX in conjunction with conventional categorical diagnoses. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX. The disruptive emotion/behavior subscale of the DMX-12 may be the most helpful in distinguishing patients with DMX from non-mixed patients.; 学位論文
• Access Restrictions: インターネット公開
• Rights (production): © 2019 Shinzato et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License; http://creativecommons.org/licenses/by-nc/3.0/
• Related Material (DOI): 10.2147/NDT.S215478
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 琉球大学 : 琉球大学学術リポジトリ

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