Quantitative Emphysema Measurement On Ultra-High-Resolution CT Scans

• Material Type: 博士論文
• Title: Quantitative Emphysema Measurement On Ultra-High-Resolution CT Scans
• Author/Editor: Xu, Yanyan; 徐, 妍妍
• Author Heading: Xu, Yanyan; 徐, 妍妍
• Publication, Distribution, etc.: University of the Ryukyus
• Publication Date: 2019-10-08
• Publication Date (W3CDTF): 2019-10-08
• Periodical title: International Journal of Chronic Obstructive Pulmonary Disease
• No. or year of volume/issue: 14
• Volume: 14
• Pages: 2283-2290
• ISSN (Periodical Title): ISSN : 1178-2005
• Degree grantor/type: 琉球大学
• Date Granted: 2020-01-29
• Dissertation Number: 乙第227号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: chronic obstructive pulmonary disease; computed tomography; emphysema; ultra-high-resolution CT; quantitative measurement
• Target Audience: 一般
• Note (General): Purpose: To evaluate the advantages of ultra-high-resolution computed tomography (U-HRCT) scans for the quantitative measurement of emphysematous lesions over conventional HRCTscans. Materials and methods: This study included 32 smokers under routine clinical care who underwent chest CT performed by a U-HRCT scanner. Chronic obstructive pulmonary disease (COPD) was diagnosed in 13 of the 32 participants. Scan data were reconstructed by 2 different protocols: i) U-HRCT mode with a 1024×1024 matrix and 0.25-mm slice thickness and ii) conventional HRCT mode with a 512×512 matrix and 0.5-mm slice thickness. On both types of scans, lesions of emphysema were quantitatively assessed as percentage of low attenuation volume (LAV%, <−950 Hounsfield units). LAV% values determined for scan data from the U-HRCT and conventional HRCT modes were compared by the Wilcoxon matched-pairs signed rank test. The association between LAV% and forced expiratory volume in 1 s per forced vital capacity (FEV_1/FVC) was assessed by the Spearman rank correlation test. Results: Mean values for LAV% determined for the U-HRCT and conventional HRCT modes were 8.9 ± 8.8% and 7.3 ± 8.4%, respectively (P<0.0001). The correlation coefficients for LAV% and FEV_1/FVC on the U-HRCT and conventional HRCT modes were 0.50 and 0.49, respectively (both P<0.01). Conclusion: Compared with conventional HRCT scans, U-HRCT scans reveal emphysematous lesions in greater detail, and provide slightly increased correlation with airflow limitation.; 学位論文
• Access Restrictions: インターネット公開
• Rights (production): © 2019 Xu et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License; http://creativecommons.org/licenses/by-nc/3.0/
• Related Material (DOI): 10.2147/COPD.S223605
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 琉球大学 : 琉球大学学術リポジトリ

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