高血糖が血管内皮細胞および肝細胞に及ぼす影響に関する基礎研究

Material type: 文書・図像類

Author: 岡本, 恭子ほか

Publisher: 長崎県立大学

Publication date: 2021-08-12

Material Format: Digital

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Note (General)：: type:OtherChronically elevated intraocular pressure (IOP) is the major risk factorof primary open-angle glaucoma, a leading cause of lindness. Dysfunc...

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Material Type: 文書・図像類
Title: 高血糖が血管内皮細胞および肝細胞に及ぼす影響に関する基礎研究
Author/Editor: 岡本, 恭子
ジェッテン, アントン M.
カン, ホンスン
OKAMOTO, Kyoko
JETTEN, Anton M.
KANG, Hong Soon
Author Heading: 岡本, 恭子
ジェッテン, アントン M.
カン, ホンスン
OKAMOTO, Kyoko
JETTEN, Anton M.
KANG, Hong Soon
Publication, Distribution, etc.: 長崎県立大学
Publication Date: 2021-08-12
Publication Date (W3CDTF): 2021-08-12
Alternative Title: GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated withglaucoma in humans.
Periodical title: 学長裁量研究成果報告書
No. or year of volume/issue: 令和3年度シーボルト校
Volume: 令和3年度
Issue: シーボルト校
Pages: 1-2
Text Language Code: jpn
Subject Heading: intraocular pressure
Glaucoma
GLI-similar-1
Target Audience: 一般
Note (General): type:Other
Chronically elevated intraocular pressure (IOP) is the major risk factorof primary open-angle glaucoma, a leading cause of lindness. Dysfunctionof the trabecular meshwork (TM), which controls the outflow of aqueoushumor (AqH) from the anterior chamber, is the major cause of elevated IOP.Here, we demonstrate that mice ficient in the Krüppel-like zinc fingertranscriptional factor GLI-similar-1 (GLIS1) develop chronically elevatedIOP. Magnetic resonance aging and histopathological analysis reveal thatdeficiency in GLIS1 expression induces progressive degeneration of the TM,eading to inefficient AqH drainage from the anterior chamber and elevatedIOP. Transcriptome and cistrome analyses identified several glaucoma- andextracellular matrix-associated genes as direct transcriptional targets ofGLIS1. We also identified a significant association between GLIS1 variantrs941125 and glaucoma in humans (P = 4.73 × 10−6), further supporting arole for GLIS1 into laucoma etiology. Our study identifies GLIS1 as acritical legulator of TM function and maintenance, AqH dynamics, and IOP.
identifier:http://reposit.sun.ac.jp/dspace/handle/10561/1945
Source: http://reposit.sun.ac.jp/dspace/bitstream/10561/1945/1/R3%e3%82%b7_okamoto.pdf
http://reposit.sun.ac.jp/dspace/bitstream/10561/1945/1/R3%e3%82%b7_okamoto.pdf
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎県立大学 : 長崎県立大学学術リポジトリ