Effects of arterial ischemia and venous congestion on the lumbar nerve root in dogs

• Material Type: 文書・図像類
• Title: Effects of arterial ischemia and venous congestion on the lumbar nerve root in dogs
• Author/Editor: KOBAYASHI, Shigeru; TAKENO, Kenichi; MIYAZAKI, Tsuyoshi; KUBOTA, Masafumi; SHIMADA, Seichior; YAYAMA, Takafumi; UCHIDA, Kenzo; NORMURA, Eiki; MWAKA, Erisa; BABA, Hisatoshi
• Author Heading: KOBAYASHI, Shigeru; TAKENO, Kenichi; MIYAZAKI, Tsuyoshi; KUBOTA, Masafumi; SHIMADA, Seichior; YAYAMA, Takafumi; UCHIDA, Kenzo; NORMURA, Eiki; MWAKA, Erisa; BABA, Hisatoshi
• Publication, Distribution, etc.: John Wiley & Sons
• Publication Date: 2008-11
• Publication Date (W3CDTF): 2008-11
• Periodical title: Journal of Orthopaedic Research
• No. or year of volume/issue: 26 11
• Volume: 26
• Issue: 11
• Pages: 1533-1540
• Text Language Code: eng
• Subject Heading: nerve root; lumbar canal stenosis; intermittent claudication; blood flow; venous congestion
• Target Audience: 一般
• Note (General): The development of radiculopathy in patients with lumbar canal stenosis is thought to be closely related to intraradicular edema resulting from compression. However, there is little agreement as to question which is more essential for intermittent claudication: ischemia or congestion. The aim of the present experimental investigation was to examine the effect of ischemia and congestion on the nerve root using dogs. The aorta was clamped as an ischemia model of the nerve root and the inferior vena cava was clamped as a congestion model at the sixth costal level for 30 min using forceps transpleurally. Measurements of blood flow, partial oxygen pressure, and conduction velocity in the nerve root were repeated over a period of 1 h after release of clamping. Finally, we examined the status of intraradicular blood-nerve barrier under fluorescence and transmission electron microscope. Immediately after clamping of the inferior vena cava, the central venous pressure increased by about four times and marked extravasation of protein tracers was induced in the lumbar nerve root. Blood flow, partial oxygen pressure, and conduction velocity of the nerve root were more severely affected by aorta clamp, but this ischemia model did not show any intraradicular edema. The blood-nerve barrier in the nerve root was more easily broken by venous congestion than by arterial ishemia. In conclusion, venous congestion may be an essential factor precipitating circulatory disturbance in compressed nerve roots and inducing neurogenic intermittent claudication.
• Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19759&item_no=1&attribute_id=22&file_no=1
• Access Restrictions: 限定公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ