Dynamic Changes of Constituents in Bronchoalveolar Lavage Fluid in Experimental Silicotic Rats

Material type: 文書・図像類

Author: ZHANG, Qunweiほか

Publisher: National Institute of Occupational Safety and Health

Publication date: 1996-10

Material Format: Digital

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Note (General)：: Bronchoalveolar lavage (BAL) is a useful and safe method for sampling cellular and biochemical components from the lung. Analysis of bronchoaveolar la...

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Material Type: 文書・図像類
Title: Dynamic Changes of Constituents in Bronchoalveolar Lavage Fluid in Experimental Silicotic Rats
Author/Editor: ZHANG, Qunwei
KUSAKA, Yukinori
ZHANG, Qifeng
HE, Linyuan
ZHANG, Zhaohe
SATO, Kazuhiro
Author Heading: ZHANG, Qunwei
KUSAKA, Yukinori
ZHANG, Qifeng
HE, Linyuan
ZHANG, Zhaohe
SATO, Kazuhiro
Publication, Distribution, etc.: National Institute of Occupational Safety and Health
Publication Date: 1996-10
Publication Date (W3CDTF): 1996-10
Periodical title: Industrial Health
No. or year of volume/issue: 34 4
Volume: 34
Issue: 4
Pages: 379-388
Text Language Code: eng
Subject Heading: Quartz
Experimental silicosis
Bronchoalveolar lavage
Bronchoalveolar lavage fluid
Target Audience: 一般
Note (General): Bronchoalveolar lavage (BAL) is a useful and safe method for sampling cellular and biochemical components from the lung. Analysis of bronchoaveolar lavage fluid (BALF)constituents is useful for defining the stage of disease and for assessing disease progression and the response to therapy in lung disorders. We studied the dynamic changes in various indices for BALF and the accompanying silicotic changes in the lungs of rats at different times after quartz instillation. Total cell counts, LDH activity, protein concentration and lipoperoxide (LPO) in the BALF of experimental silicotic rats were significantly higher than those of control rats (p < 0.05 or 0.01). After instillation, quartz content, total cell counts, LDH activity and protein concentration in BALE tended to decrease over time. These findings suggested that in acute silicosis, quartz can induce serious inflammatio and damage the lung, with acute lung proteinosis seen as the main change in this stage.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19894&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19894&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ