Temperature-dependent Specific Transport of Levofloxacin in Human Intestinal Epithelial LS180 Cells

Material type: 文書・図像類

Author: FUKUMORI, Shiroほか

Publisher: Wiley

Publication date: 2009

Material Format: Digital

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Note (General)：: It was reported previously that specific levofloxacin uptake in Caco- 2 cells was inhibited by nicotine, enalapril, L-carnitine and fexofenadine. The ...

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Material Type: 文書・図像類
Title: Temperature-dependent Specific Transport of Levofloxacin in Human Intestinal Epithelial LS180 Cells
Author/Editor: FUKUMORI, Shiro
MASAGO, Miki
ISHIDA, Kazuya
KAYANO, Yuichiro
TAGUTHI, Masato
HASHIMOTO, Yukiya
Author Heading: FUKUMORI, Shiro
MASAGO, Miki
ISHIDA, Kazuya
KAYANO, Yuichiro
TAGUTHI, Masato
HASHIMOTO, Yukiya
Publication, Distribution, etc.: Wiley
Publication Date: 2009
Publication Date (W3CDTF): 2009
Periodical title: Biopharmaceutics & Drug Disposition
No. or year of volume/issue: 30 8
Volume: 30
Issue: 8
Pages: 448-456
Text Language Code: eng
Subject Heading: levofloxacin
OATP
OCTN
LS180
cells
Caco-2cells
Target Audience: 一般
Note (General): It was reported previously that specific levofloxacin uptake in Caco- 2 cells was inhibited by nicotine, enalapril, L-carnitine and fexofenadine. The aim of the present study was to characterize the cellular uptake of levofloxacin using another human intestinal cell, line, LS180. Levofloxacin uptake in LS180 cells was temperature-dependent and optimal at neutral pH, but was Na+-independent. The rank order of inhibitory effects of the four compoundson[14C]levofloxacin uptake in LS180 cells was nicotine>enalapril> L- carnitine> fexofenadine, which is consistent with that in Caco- 2 cells. The mRNA levels of OATP1A2, 1B1, 1B3 and 2B1 in LS180 cells were markedly different from those in Caco-2 cells, and OATP substrates/inhibitors had no systematic effect on thelevofloxacin uptake.The mRNA levels of OCTN1 and 2 in LS180 cells were similar to those inCaco-2 cells.However, the inhibitory effect of nicotine on L-[3H]carnitine uptake was much less potent than that of unlabeled L-carnitine. These results in dicate that the specific uptake system for levofloxacin in LS180 cells isidentical/similar to that in Caco-2 cells, but that OATPs and OCTNs contribute little to levofloxacin uptake in the human intestinal epithelial cells.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19953&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19953&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ