Different Effects of Calcium Channel Blockers on Matrix

Material type: 文書・図像類

Author: YUE, Hongほか

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Publication date: 2000-08

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Note (General)：: The cardiac effects of calcium channel blockers(CCBs)related to cardiac remodeling are inconsistent. Matrix metalloprotein-ases(MMPs)contribute to tis...

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Material Type: 文書・図像類
Title: Different Effects of Calcium Channel Blockers on Matrix
Author/Editor: YUE, Hong
UZUI, Hiroyasu
SHIMIZU, Hiromasa
NAKANO, Akira
MITSUKE, Yasuhiko
UEDA, Takanori
LEE, Jong-Dae
Author Heading: YUE, Hong
UZUI, Hiroyasu
SHIMIZU, Hiromasa
NAKANO, Akira
MITSUKE, Yasuhiko
UEDA, Takanori
LEE, Jong-Dae
Publication Date: 2000-08
Publication Date (W3CDTF): 2000-08
Periodical title: Journal of Cardiovasc Pharmacol
No. or year of volume/issue: 44 2
Volume: 44
Issue: 2
Pages: 223-230
Text Language Code: eng
Subject Heading: calcium channel blocker
matrix metalloproteinase
fibroblasts
nitric oxide
protein tyrosine kinase
Target Audience: 一般
Note (General): The cardiac effects of calcium channel blockers(CCBs)related to cardiac remodeling are inconsistent. Matrix metalloprotein-ases(MMPs)contribute to tissue remodeling. Cardiac fibroblasts play an important role in the regulation of collagen degradation by MMPs. Using gelatin zymography, Western blotting, Griess reagent, and a calcium kit-fluo3, we investigated the effects of nifedipine, verapamil, diltiazem, and amlodipine on MMP-2 expression and fur-ther elucidate the mechanisms in cultured rat cardiac fibroblasts. Ni-fedipine increased and amlodipine decreased the expression of MMP-2; however, neither verapamil nor diltiazem altered MMP-2 expression. Nifedipine also increased nitrite production, and this in-crease was blunted by a nitric oxide(NO)synthases inhibitor(L-NAME).Nifedipine-induced MMP-2 expression was also blunted by L-NAME. An NO donor(sodiumnitroprusside)induced MMP-2 ex-pression. Data indicated that nifedipine might increase MMP-2 ex-pression through a possible NO-dependent pathway. Amlodipine had no influence on nitrite production. The amlodipine-induced decrease of MMP-2 expression was abolished by two protein tyrosine kinase inhibitors, genistein and herbimycin A, indicating that amlodipine might decrease MMP-2 expression through a possible protein tyro-sine kinase pathway. None of the four CCBs could alter the fluosce-nce intensity of fluo3, indicating that the effects of CCBs on MMP-2 expression were independent of the variation in intracellular Ca2+ concentration. Our findings revealed that different CCBs exerted dif-ferent effects on MMP-2 expression in cardiac fibroblasts.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ