Effects of magnesium on the production of extracellular matrix metalloproteinases in cultured rat vascular smooth muscle cells

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Author: YUE, Hongほか

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Publication date: 2003

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Note (General)：: The precise correlation between magnesium and cardiovascular disease remains to be established. Matrix metalloproteinases(MMPs)are expressed inc orona...

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Material Type: 文書・図像類
Title: Effects of magnesium on the production of extracellular matrix metalloproteinases in cultured rat vascular smooth muscle cells
Author/Editor: YUE, Hong
LEE, Jong-Dae
SHIMIZU, Hiromasa
UZUI, Hiroyasu
MITSUKE, Yasuhiko
UEDA, Takanori
Author Heading: YUE, Hong
LEE, Jong-Dae
SHIMIZU, Hiromasa
UZUI, Hiroyasu
MITSUKE, Yasuhiko
UEDA, Takanori
Publication Date: 2003
Publication Date (W3CDTF): 2003
Periodical title: Atherosclerosis
No. or year of volume/issue: 166
Volume: 166
Pages: 271-277
Text Language Code: eng
Subject Heading: Magnesium
Matrix metalloproteinase
Atherosclerosis
Smooth muscle cell
Target Audience: 一般
Note (General): The precise correlation between magnesium and cardiovascular disease remains to be established. Matrix metalloproteinases(MMPs)are expressed inc oronary arterial atherosclerotic lesions. MMP production in vascular smooth muscle cells(VSMCs)is stimulated by growth factors such as platelet-derived growth factor(PDGF). To assess the association between magnesium and MMPs, we examined the effects of different extracellular magnesium concentrations(0 /3.0mmol/l)on MMPs production in cultured rat VSMCs under basal and PDGF-stimulated conditions usingg elatin zymography and western blotting. As magnesium is called a natural calcium antagonist, we further compared the effects of magnesium with some calcium antagonists. Magnesium reduced MMP-2 production dose-dependently at basal and PDGF-stimulated conditions in VSMCs.However,neitherverapamilnornifedipineinfluenced MMP-2 production under any conditions examined. The effect of magnesium on the production of MMP-2 was inhibited by two tyrosine kinase inhibitors-genistein and herbimycin A. The results of this study indicate that extracellularly added magnesium decreased MMPs secretion, which appears to be associated with protein tyrosine kinase.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ