Direct effect of vanadium on citrate uptake by rat renal brush border membrane vesicles (BBMV)

Material type: 文書・図像類

Author: SATO, Kazuhiroほか

Publisher: 独立行政法人労働安全衛生総合研究所

Publication date: 2002-07

Material Format: Digital

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Note (General)：: Vanadium pentoxide is used as a catalyst and a ferrovanadium alloy ingredient inautomotive steels and in jet engines and airframes. In addition, vana...

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Material Type: 文書・図像類
Title: Direct effect of vanadium on citrate uptake by rat renal brush border membrane vesicles (BBMV)
Author/Editor: SATO, Kazuhiro
KUSAKA, Yukinori
KANAMARU, Hiroshi
OKADA, Kenichiro
Author Heading: SATO, Kazuhiro
KUSAKA, Yukinori
KANAMARU, Hiroshi
OKADA, Kenichiro
Publication, Distribution, etc.: 独立行政法人労働安全衛生総合研究所
Publication Date: 2002-07
Publication Date (W3CDTF): 2002-07
Periodical title: Industrial health
No. or year of volume/issue: 40 3
Volume: 40
Issue: 3
Pages: 278-281
Text Language Code: eng
Subject Heading: Vanadium pentoxide
Citrate
Rat renal brush border membrane vesicles (BBMV)
Target Audience: 一般
Note (General): Vanadium pentoxide is used as a catalyst and a ferrovanadium alloy ingredient inautomotive steels and in jet engines and airframes. In addition, vanadium is found in fuel oils.Thus, occupational exposures to vanadium pentoxide and trioxide may occur during the cleaning ofoil-fired ship boilers, and from oil-fired power station boilers. Occupational exposure to vanadiumpentoxide induces green tongue, asthmatic symptoms and albuminuria with cast. Urinary citrate isfreely filtered at the glomerulus, and its reabsorption in the proximal tubule is the major determinantof the rate of renal excretion. In this study, we exposed rat renal brush border membrane vesicles(BBMV) to vanadium pentoxide and examined their citrate uptake characteristics. The preincubationof BBMV with 1 mM V2O5 for 8 hours significantly inhibited citrate uptake compared with that ofBBMV without V2O5 preincubation. These findings indicate that the preincubation of BBMV withvanadium pentoxide results in a time-dependent inhibition of citrate uptake by BBMV. These findings might contribute to nephrotoxicity in vanadium exposure.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20051&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20051&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ