Effect of Platinum Coordination Complex (PtCx) onCitrate Uptake by Rat Renal Brush Border Membrane Vesicles (BBMV): Cisplatin-Intoxicated Rats

Material type: 文書・図像類

Author: SATO, Kazuhiroほか

Publisher: 独立行政法人労働安全衛生総合研究所

Publication date: 2001-10

Material Format: Digital

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Note (General)：: Platinosis with severe dermatitis and/or asthma is broadly defined as the effects of solubleplatinum salts on people exposed to them occupationally. ...

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Material Type: 文書・図像類
Title: Effect of Platinum Coordination Complex (PtCx) onCitrate Uptake by Rat Renal Brush Border Membrane Vesicles (BBMV): Cisplatin-Intoxicated Rats
Author/Editor: SATO, Kazuhiro
KUSAKA, Yukinori
CHIBA, Yukio
OKADA, Kenichiro
Author Heading: SATO, Kazuhiro
KUSAKA, Yukinori
CHIBA, Yukio
OKADA, Kenichiro
Publication, Distribution, etc.: 独立行政法人労働安全衛生総合研究所
Publication Date: 2001-10
Publication Date (W3CDTF): 2001-10
Periodical title: Industrial health
No. or year of volume/issue: 39 4
Volume: 39
Issue: 4
Pages: 317-321
Text Language Code: eng
Subject Heading: Platinum
Cisplatin
Citrate
Brush border membrane vesicles
Target Audience: 一般
Note (General): Platinosis with severe dermatitis and/or asthma is broadly defined as the effects of solubleplatinum salts on people exposed to them occupationally. Platinum coordination complexes arewidely used in the treatment of a variety of solid tumors. However, the clinical use of cisplatin, themost useful agent, is limited by the development of nephrotoxicity. Thus, an accidental exposure tosoluble platinum at a high dose in platinum refineries and pharmaceutical factories could induceoccupational nephrotoxicity. Urinary citrate is freely filtered at the glomerulus, and its reabsorptionin the proximal tubule is the major determinant of the rate of renal excretion. In our previousstudies, we found that the preincubation of rat renal brush border membrane vesicles (BBMV) withcisplatin and carboplatin, a second-generation platinum coordination complex, significantly inhibitedthe citrate uptake compared with that of the control BBMV. In this study, we performed in vivoexpriments in cisplatin-intoxicated rats to elucidate the toxic mechanism of cisplatin. And our resultsshowed that the citrate uptake was significantly inhibited in cisplatin-intoxicated rats at 1 min compared with that of control rats.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ