Citrate Uptake by Isolated Rat Renal Brush Border Membrane Vesicles in Cadmium-Intoxicated Rats

Material type: 文書・図像類

Author: SATO, Kazuhiroほか

Publisher: 独立行政法人労働安全衛生総合研究所

Publication date: 1997-07

Material Format: Digital

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Note (General)：: Epidemiological Studies have reported that the formation of renal stones is often observed in workers exposed to cadmium (Cd). Citrate is known to be ...

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Material Type: 文書・図像類
Title: Citrate Uptake by Isolated Rat Renal Brush Border Membrane Vesicles in Cadmium-Intoxicated Rats
Author/Editor: SATO, Kazuhiro
KUSAKA, Yukinori
ZHANG, Qunwei
LI, Benyi
OKADA, Kenichiro
NAKAKUKI, Kazuya
MURAOKA, Ryusuke
Author Heading: SATO, Kazuhiro
KUSAKA, Yukinori
ZHANG, Qunwei
LI, Benyi
OKADA, Kenichiro
NAKAKUKI, Kazuya
MURAOKA, Ryusuke
Publication, Distribution, etc.: 独立行政法人労働安全衛生総合研究所
Publication Date: 1997-07
Publication Date (W3CDTF): 1997-07
Periodical title: Industrial health
No. or year of volume/issue: 35 3
Volume: 35
Issue: 3
Pages: 388-393
Text Language Code: eng
Subject Heading: Cadmium
Renal stones
Brush border membrane vesicles
Target Audience: 一般
Note (General): Epidemiological Studies have reported that the formation of renal stones is often observed in workers exposed to cadmium (Cd). Citrate is known to be a protective factor against renal stone formation. We previously reported that direct exposure to high-level cadmium impaired the citrate uptake by the brush border membrane vesicles (BBMV), which may mean that the formation of renal stones from exposure to Cd could be prevented. In the present study, to clarify the mechanism of Cd-induced renal stone formation, the characteristics of BBMV-induced citrate uptake were determined in Cd-intoxicated rats. Cd intoxication was induced by daily subcutaneous injections of CdC12 at a dose of 2 mg Cd/kg body wt per day for 17 to 20 days. The BBMV were prepared by the divalent cation precipitation method. Citrate uptake was measured by the Millipore rapid membrane filtration technique. The citrate uptake per mg protein was not significantly different between the two groups. The volume of BBMV was significantly reduced (50%) in Cd-intoxicated rats compared with that of control rats. Percentages of the equilibrium value were also significantly inhibited in Cd-intoxicated rats.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ