Cycle Flux Algebra for Ion and Water Flux through the KcsA Channel Single-File Pore Links Microscopic Trajectories and Macroscopic Observables

Material type: 文書・図像類

Author: OIKI, Shigetoshiほか

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Publication date: 2011-01

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Note (General)：: In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other. Under such constraints, ion and wate...

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Material Type: 文書・図像類
Title: Cycle Flux Algebra for Ion and Water Flux through the KcsA Channel Single-File Pore Links Microscopic Trajectories and Macroscopic Observables
Author/Editor: OIKI, Shigetoshi
IWAMOTO, Masayuki
SUMIKAMA, Takashi
Author Heading: OIKI, Shigetoshi
IWAMOTO, Masayuki
SUMIKAMA, Takashi
Publication Date: 2011-01
Publication Date (W3CDTF): 2011-01
Periodical title: PLoS ONE
No. or year of volume/issue: 6 1
Volume: 6
Issue: 1
Pages: e16578-
Text Language Code: eng
Target Audience: 一般
Note (General): In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other. Under such constraints, ion and water fluxes are coupled, leading to experimentally observable phenomena such as the streaming potential. Analysis of this coupled flux would provide unprecedented insights into the mechanism of permeation. In this study, ion and water permeation through the KcsA potassium channel was the focus, for which an eight-statediscrete-state Markov model has been proposed based on the crystal structure, exhibiting fourion-binding sites. Random transitions on the model lead to the generation of the net flux. Here we introduced the concept of cycle flux to derive exact solutions of experimental observables from the permeation model. There are multiple cyclic paths on the model,and random transitions complete the cycles. The rate of cycle completion is called the cycle flux. The net flux is generated by a combination of cyclic paths with their own cycle flux. T.L.Hill developed a graphical method of exact solutions for the cycle flux. This method was extended to calculate one-way cycle fluxes of the KcsA channel. By assigning the stoichiometric numbers for ion and water transfer to each cycle, we established a method to calculate the water-ion coupling ratio(CRw-i)through cycle flux algebra. These calculations predicted that CRw-i would increase at low potassium concentrations. One envisions an intuitive picture of permeation as random transitions among cyclic paths, and the relative contributions of the cycle fluxes afford experimental observables.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20106&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20106&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ