IL-17A/F Modulates Fibrocyte Functions in Cooperation with CD40-Mediated Signaling.

• Material Type: 文書・図像類
• Title: IL-17A/F Modulates Fibrocyte Functions in Cooperation with CD40-Mediated Signaling.
• Author/Editor: Hisako, Hayashi; Akiko, Kawakita; Shintaro, Okazaki; Motoko, Yasutomi; Hiroki, Murai; Yusei, Ohshima
• Author Heading: Hisako, Hayashi; Akiko, Kawakita; Shintaro, Okazaki; Motoko, Yasutomi; Hiroki, Murai; Yusei, Ohshima
• Publication Date: 2013
• Publication Date (W3CDTF): 2013
• Periodical title: Inflammation
• Text Language Code: eng
• Subject Heading: IL-17A; IL-17F; fibrocytes; airway remodeling; CD40
• Target Audience: 一般
• Note (General): T helper 17 (Th17) cells that produce Interleukin (IL)-17A and IL-17F have been found to participate in the development of bronchial asthma and bleomycin-induced pulmonary fibrosis. However, whether they play a causative role in the airway remodeling observed in these respiratory diseases remains unclear. Because fibrocytes are involved in tissue repair and fibrosis, and are presumably precursors of lung fibroblasts and myofibroblasts, we examined the effects of IL-17A/F on fibrocyte functions. Both IL-17A and IL-17F enhanced fibrocytes' α-smooth muscle actin (SMA) expression. Priming fibrocytes with IL-17A enhanced their CD40-mediated IL-6 production, whereas IL-17F-priming increased the CD40-mediated mRNA expression of collagen I, vascular endothelial growth factor (VEGF), and angiogenin. CD4+ T cells co-cultured with fibrocytes produced IL-17A, which was inhibited by blocking CD40 and CD40 ligand interactions. These findings suggest that cooperative interactions between fibrocytes and Th17 cells play an important role via CD40- and IL-17A/F-mediated signaling for collagen and proangiogenic factor production, which may lead to the extracellular matrix deposition and neo-vascularization seen in airway remodeling.
• Access Restrictions: 限定公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ

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