Mucosal immunity and the onset of allergic disease

Material type: 文書・図像類

Author: Ohshima, Yusei

Publisher: -

Publication date: 2013

Material Format: Digital

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Note (General)：: Mucosal barriers encounter an environment that is rich in pathogens that possess mechanisms for invading mucosal tissues. These barriers also encounte...

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Material Type: 文書・図像類
Title: Mucosal immunity and the onset of allergic disease
Author/Editor: Ohshima, Yusei
Author Heading: Ohshima, Yusei
Publication Date: 2013
Publication Date (W3CDTF): 2013
Periodical title: Allergology International
No. or year of volume/issue: 62
Volume: 62
Pages: 279-289
ISSN (Periodical Title): ISSN : 1323-8930
Text Language Code: eng
Target Audience: 一般
Note (General): Mucosal barriers encounter an environment that is rich in pathogens that possess mechanisms for invading mucosal tissues. These barriers also encounter innocuous antigens, such as foods, airborne antigens, and microbiota. The mucosa has developed a sophisticated immune system that can mount robust immune responses against pathogenic antigens, while maintaining mucosal tolerance against non-pathogenic antigens. Accumulating evidence indicates that the mucosal epithelium, dendritic cells, and a subtype of T cells with regulatory properties play important roles in the development and maintenance of mucosal tolerance. Moreover, the micribiota also contribute to regulating the mucosal immune system. A failure to develop or the breakdown of mucosal tolerance can result in allergic diseases, such as food allergy and asthma. By taking advantage of the unique characteristics of the mucosal immune system, strategies that induce regulatory cells in vivo and, thereby, reconstitute mucosal tolerance may be used to develop novel therapies that are suitable for treating or preventing of allergic diseases.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ