Intercellular and Intracellular Signaling Pathways Mediating Ionizing Radiation-Induced Bystander Effects

Material type: 文書・図像類

Author: HAMADA, Nobuyukiほか

Publisher: Japan Radiation Research Society

Publication date: 2007-01

Material Format: Digital

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Note (General)：: A rapidly growing body of experimental evidence indicates that ionizing radiation induces biological effects in non-irradiated bystander cells that ha...

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Material Type: 文書・図像類
Title: Intercellular and Intracellular Signaling Pathways Mediating Ionizing Radiation-Induced Bystander Effects
Author/Editor: HAMADA, Nobuyuki
MATSUMOTO, Hideki
HARA, Takamitsu
KOBAYASHI, Yasuhiko
Author Heading: HAMADA, Nobuyuki
MATSUMOTO, Hideki
HARA, Takamitsu
KOBAYASHI, Yasuhiko
Publication, Distribution, etc.: Japan Radiation Research Society
Publication Date: 2007-01
Publication Date (W3CDTF): 2007-01
Periodical title: Journal of Radiation Research
No. or year of volume/issue: 48 2
Volume: 48
Issue: 2
Pages: 87-95
Text Language Code: eng
Subject Heading: Ionizing radiation
Bystander effects
Signaling pathways
Plasma membrane
Radiotherapy
Target Audience: 一般
Note (General): A rapidly growing body of experimental evidence indicates that ionizing radiation induces biological effects in non-irradiated bystander cells that have received signals from adjacent or distant irradiated cells. This phenomenon, which has been termed the ionizing radiation-induced bystander effect, challenges the long-standing paradigm that radiation traversal through the nucleus of a cell is a prerequisite to elicit genetic damage or a biological response. Bystander effects have been observed in a number of experimental systems, and cells whose nucleus or cytoplasm is irradiated exert bystander responses. Bystander cells manifest a multitude of biological consequences, such as genetic and epigenetic changes, alterations in gene expression, activation of signal transduction pathways, and delayed effects in their progeny. Several mediating mechanisms have been proposed. These involve gap junction-mediated intercellular communication, secreted soluble factors, oxidative metabolism, plasma membrane-bound lipid rafts, and calcium fluxes. This paper reviews briefly the current knowledge of the bystander effect with a focus on proposed mechanisms. The potential benefit of bystander effects to cancer radiotherapy will also be discussed.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20404&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20404&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Rights (production): 本文データは学協会の許諾に基づきCiNiiから複製したものである
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ