Improvement of bladder storage function by α1-blocker depends on the suppression of C-fiber afferent activity in rats

Material type: 文書・図像類

Author: YOKOYAMA, Osamuほか

Publisher: John Wiley & Sons

Publication date: 2006

Material Format: Digital

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Note (General)：: Aims α1-blockers improve voiding symptoms through the reduction of prostatic and urethral smooth muscle tone; however, the underlying mechanism of imp...

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Material Type: 文書・図像類
Title: Improvement of bladder storage function by α1-blocker depends on the suppression of C-fiber afferent activity in rats
Author/Editor: YOKOYAMA, Osamu
YUSUP, Anwar
OYAMA, Nobuyuki
AOKI, Yoshitaka
TANASE, Kazuya
MATSUTA, Yosuke
MIWA, Yoshiji
AKINO, Hironobu
Author Heading: YOKOYAMA, Osamu
YUSUP, Anwar
OYAMA, Nobuyuki
AOKI, Yoshitaka
TANASE, Kazuya
MATSUTA, Yosuke
MIWA, Yoshiji
AKINO, Hironobu
Publication, Distribution, etc.: John Wiley & Sons
Publication Date: 2006
Publication Date (W3CDTF): 2006
Periodical title: Neurourology and urodynamics
No. or year of volume/issue: 25 5
Volume: 25
Issue: 5
Pages: 461-467
Text Language Code: eng
Subject Heading: C-fiber
α1-blockers
detrusor overactivity
cerebral infarction
rat
Target Audience: 一般
Note (General): Aims α1-blockers improve voiding symptoms through the reduction of prostatic and urethral smooth muscle tone; however, the underlying mechanism of improvement of storage symptoms is not known. Using a rat model of detrusor overactivity caused by cerebral infarction (CI), we undertook the present study to determine whether the effect of an 1-blocker, naftopidil, is dependent on the suppression of C-fiber afferents. Methods To induce desensitization of C-fiber bladder afferents, we injected resiniferatoxin (0.3 mg/kg, RTX) sub-cutaneously to female Sprague-Dawley rats 2 days prior to left middle cerebral artery occlusion (MCAO) (RTX-CI rats). As controls we used rats without RTX treatment (CI rats). MCAO and insertion of a polyethylene catheter through the bladder dome were performed under halothane anesthesia. We investigated the effects on cystometrography (CMG) of intravenous (i.v.), intracerebroventricular (i.c.v.), or intrathecal (i.t.) administration of naftopidil in conscious CI rats. Results Bladder capacity (BC) was markedly reduced after MCAO in both RTX-CI and CI rats. I.v. administration of naftopidil significantly increased BC in CI rats without an increase in residual volume, but it had no effects on BC in RTX-CI rats. I.t. administration of naftopidil significantly increased BC in CI but not in RTX-CI rats. Conclusions These results suggest that naftopidil has an inhibitory effect on C-fiber afferents in the lumbosacral spinal cord, improving BC during the storage phase.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20599&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20599&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ