Yrb1p Interaction with the Gsp1p C Terminus Blocks Mog1p Stimulation of GTP Release from Gsp1p

Material type: 文書・図像類

Author: OKI, Masayaほか

Publisher: The American Society for Biochemistry and Molecular Biology

Publication date: 2000-10-20

Material Format: Digital

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Note (General)：: Mog1p, a multicopy suppressor of gsp1, the temperature-sensitive mutant of the Saccharomyces cerevisiae Ran homologue, binds to GTP-Gsp1p but not to G...

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Material Type: 文書・図像類
Title: Yrb1p Interaction with the Gsp1p C Terminus Blocks Mog1p Stimulation of GTP Release from Gsp1p
Author/Editor: OKI, Masaya
NISHIMOTO, Takeharu
Author Heading: OKI, Masaya
NISHIMOTO, Takeharu
Publication, Distribution, etc.: The American Society for Biochemistry and Molecular Biology
Publication Date: 2000-10-20
Publication Date (W3CDTF): 2000-10-20
Periodical title: The Journal of Biological Chemistry
No. or year of volume/issue: 275 42
Volume: 275
Issue: 42
Pages: 32894-32900
Text Language Code: eng
Target Audience: 一般
Note (General): Mog1p, a multicopy suppressor of gsp1, the temperature-sensitive mutant of the Saccharomyces cerevisiae Ran homologue, binds to GTP-Gsp1p but not to GDP-Gsp1p. The function of Mog1p in the Ran cycle is as yet unknown. This study found that Mog1p releases a nucleotide from GTP-Gsp1p but not from GDP-Gsp1p. Yrb1p, the S. cerevisiae homologue of RanBP1, which is a strong inhibitor of RCC1-stimulated nucleotide release, also inhibited the Mog1p-stimulated nucleotide release from GTP-Gsp1p. At a concentration corresponding to the molar concentration of GTP-Gsp1p, Yrb1p completely inhibited the Mog1p-stimulated nucleotide release. Consistently, the Yrb1p•GTP-Gsp1p complex was more stable than the Mog1p•GTP-Gsp1p complex. Yrb1p did not inhibit the Mog1p-stimulated nucleotide release from GTP-Gsp1ΔC. The Gsp1ΔC protein lacks the final eight amino acids of the C terminus, and for this reason, the interaction between GTP-Gsp1ΔC and Yrb1p was strongly reduced. On the other hand, Mog1p binds to GTP-Gsp1ΔC more efficiently than to GTP-Gsp1p.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ