Nitric oxide-dependent long-term potentiation revealed by real-time imaging of nitric oxide production and neuronal excitation in the dorsal horn of rat spinal cord slices

Material type: 文書・図像類

Author: IKEDA, Hiroshiほか

Publisher: Blackwell

Publication date: 2006-04

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: Nitric oxide (NO) is thought to be involved in the central mechanism of hyperalgesia and allodynia at the spinal level. Recently, we reported that NO ...

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｆｕｋｕｉ　Ａｃａｄｅｍｉｃ　Ｒｅｐｏｓｉｔｏｒｙ
Digital
You can check the holdings of institutions and databases with which 学術機関リポジトリデータベース（IRDB）（機関リポジトリ） is linked at the site of 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）.
Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｆｕｋｕｉ　Ａｃａｄｅｍｉｃ　Ｒｅｐｏｓｉｔｏｒｙ

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: Nitric oxide-dependent long-term potentiation revealed by real-time imaging of nitric oxide production and neuronal excitation in the dorsal horn of rat spinal cord slices
Author/Editor: IKEDA, Hiroshi
KUSUDO, Kei
MURASE, Kazuyuki
Author Heading: IKEDA, Hiroshi
KUSUDO, Kei
MURASE, Kazuyuki
Publication, Distribution, etc.: Blackwell
Publication Date: 2006-04
Publication Date (W3CDTF): 2006-04
Periodical title: European journal of neuroscience
No. or year of volume/issue: 23 7
Volume: 23
Issue: 7
Pages: 1939-1943
ISSN (Periodical Title): ISSN : 0953-816X
Text Language Code: eng
Subject Heading: hyperalgesia
neuronal plasticity
optical imaging
pain
Target Audience: 一般
Note (General): Nitric oxide (NO) is thought to be involved in the central mechanism of hyperalgesia and allodynia at the spinal level. Recently, we reported that NO played an important role in the induction of long-term potentiation (LTP) of synaptic strength in spinal dorsal horn, which is believed to underlie hyperalgesia and allodynia. In this study, to elucidate the relationship of NO to LTP in spinal dorsal horn, we measured the spatiotemporal distribution of NO signal with the NO-sensitive dye, DAR-4M, and neuronal excitation with the voltage-sensitive dye, RH482, in rat spinal cord slices, elicited by dorsal root stimulation. In superficial dorsal horn, neuronal excitation evoked by C fiber-activating dorsal root stimulation was potentiated for more than 2 h after low-frequency conditioning stimulation (LFS, 240 pulses at 2 Hz for 2 min). In the same slices that exhibited LTP, NO was produced and distributed in the superficial dorsal horn during the delivery of LFS, and the amplitude of LTP and amount of NO production showed close correlation from slice to slice. LTP and production of NO were inhibited in the presence of the NO synthase inhibitors and an inhibitor of heme oxygenase, the synthetic enzyme for carbon monoxide (CO). These results suggest that production and distribution of NO is necessary for the induction of LTP in spinal dorsal horn, and that CO contributes to the LTP induction and NO production by LFS.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=22454&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=22454&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ