Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis

Material type: 文書・図像類

Author: Umeda, Yukihiroほか

Publisher: Society of Nuclear Medicine

Publication date: 2015-12

Material Format: Digital

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Note (General)：: The aim of this prospective study was to clarify whether dual-time-point (18)F-FDG PET imaging results are useful to predict long-term survival of idi...

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Material Type: 文書・図像類
Title: Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis
Author/Editor: Umeda, Yukihiro
Demura, Yoshiki
Morikawa, Miwa
Anzai, Masaki
Kadowaki, Maiko
Ameshima, Shingo
Tsuchida, Tatsuro
Tsujikawa, Tetsuya
Kiyono, Yasushi
Okazawa, Hidehiko
Ishizaki, Takeshi
Ishizuka, Tamotsu
Author Heading: Umeda, Yukihiro
Demura, Yoshiki
Morikawa, Miwa
Anzai, Masaki
Kadowaki, Maiko
Ameshima, Shingo
Tsuchida, Tatsuro
Tsujikawa, Tetsuya
Kiyono, Yasushi
Okazawa, Hidehiko
Ishizaki, Takeshi
Ishizuka, Tamotsu
Publication, Distribution, etc.: Society of Nuclear Medicine
Publication Date: 2015-12
Publication Date (W3CDTF): 2015-12
Periodical title: Jounal of Nuclear Medicine
No. or year of volume/issue: 56 12
Volume: 56
Issue: 12
Pages: 1869-1875
Text Language Code: eng
Subject Heading: fluorodeoxyglucose 18F
idiopathic pulmonary fibrosis
positron emission tomography
survival analysis
Target Audience: 一般
Note (General): The aim of this prospective study was to clarify whether dual-time-point (18)F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. METHODS: Fifty IPF patients underwent (18)F-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after (18)F-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. RESULTS: A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64-20.3; P = 0.0001). CONCLUSION: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.
Access Restrictions: 限定公開
Related Material (DOI): 10.2967/jnumed.115.163360
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ