Metabolic monitoring of advanced uterine cervical cancer neoadjuvant chemotherapy by using [F-18]-Fluorodeoxyglucose positron emission tomography: preliminary results in three patients

Material type: 文書・図像類

Author: YOSHIDA, Yoshioほか

Publisher: Elsevier Ltd

Publication date: 2004-12

Material Format: Digital

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Note (General)：: [Objective] The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a st...

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Material Type: 文書・図像類
Title: Metabolic monitoring of advanced uterine cervical cancer neoadjuvant chemotherapy by using [F-18]-Fluorodeoxyglucose positron emission tomography: preliminary results in three patients
Author/Editor: YOSHIDA, Yoshio
KUROKAWA, Tetsuji
KAWAHARA, Kazumi
YAGIHARA, Akira
TSUCHIDA, Tatsuro
OKAZAWA, Hidehiko
FUJIBAYASHI, Yasuhisa
YONEKURA, Yoshiharu
KOTSUJI, Fumikazu
Author Heading: YOSHIDA, Yoshio
KUROKAWA, Tetsuji
KAWAHARA, Kazumi
YAGIHARA, Akira
TSUCHIDA, Tatsuro
OKAZAWA, Hidehiko
FUJIBAYASHI, Yasuhisa
YONEKURA, Yoshiharu
KOTSUJI, Fumikazu
Publication, Distribution, etc.: Elsevier Ltd
Publication Date: 2004-12
Publication Date (W3CDTF): 2004-12
Periodical title: Gynecologic Oncology
No. or year of volume/issue: 95 3
Volume: 95
Issue: 3
Pages: 597-602
Text Language Code: eng
Subject Heading: FDG-PET for monitoring treatment response
Cervical cancer
Target Audience: 一般
Note (General): [Objective] The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a standardized uptake value (SUV) by positron emission tomography (PET), to evaluate treatment response to neoadjuvant chemotherapy (NAC) in advanced uterine cervical cancer. [Methods] We briefly describe the clinical courses of three women with advanced cervical cancer who were treated with neoadjuvant chemotherapy (NAC) prior to radical hysterectomy and who were analyzed for correlation with the decrease in tumor volume by magnetic resonance imaging (MRI), in SUV by FDG-PET, and by histologic response. [Results] In these individuals, tumor volume and SUV were decreased by NAC. The decrease in SUV by FDG-PET was better correlated to histologic response for NAC than MRI was in advanced cervical cancer. [Conclusions] Measurement of SUV by FDG-PET has clinical utility in evaluating treatment response for NAC in advanced cervical cancer. Although work in this field is still in the early stages, this report demonstrates that SUV by FDG-PET has the potential to become the new standard for monitoring the treatment response of NAC in cervical cancer. This monitoring approach must be proven in a larger number of patients for both primary and secondary lesions and should be further explored in another gynecologic cancer.
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/j.ygyno.2004.08.037
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ