Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice

Material type: 文書・図像類

Author: Iino, Satoshiほか

Publisher: 国際組織細胞学会(Japan Publications Trading Co Ltd)

Publication date: 2007-08-10

Material Format: Digital

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Note (General)：: Interstitial cells of Cajal (ICC) are important regulatory cells generating electrical rhythmicity and transducing neural signals in the gastrointesti...

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Material Type: 文書・図像類
Title: Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice
Author/Editor: Iino, Satoshi
Horiguchi, Satomi
Horiguchi, Kazuhide
Najyo, Yoshiaki
Author Heading: Iino, Satoshi
Horiguchi, Satomi
Horiguchi, Kazuhide
Najyo, Yoshiaki
Publication, Distribution, etc.: 国際組織細胞学会(Japan Publications Trading Co Ltd)
Publication Date: 2007-08-10
Publication Date (W3CDTF): 2007-08-10
Periodical title: Archives of Histology and Cytology
No. or year of volume/issue: 70 3
Volume: 70
Issue: 3
Pages: 163-173
Text Language Code: eng
Target Audience: 一般
Note (General): Interstitial cells of Cajal (ICC) are important regulatory cells generating electrical rhythmicity and transducing neural signals in the gastrointestinal musculature. ICC express the proto-oncogene c-kit, a receptor tyrosine kinase, and can be examined morphologically using the c-Kit antibody. The c-kit gene is allelic with the murine white-spotting locus W, and the c-kit mutation (W mutation) affects various aspects of hematopoietic cells, germ cells, melanocytes, mast cells, and ICC and have been used to reveal its function. To search for a new model that lacks a specific type of ICC, we examined homozygous Wv/Wv black-eyed-white mice that are viable with anemia. Results showed the principal patterns of ICC deficiency were the same between the W/Wv and Wv/Wv mutants. In the stomach of both mice, intramuscular ICC (ICC-IM) were missing and myenteric ICC (ICC-MY) were reduced in number. In the small intestine, the number of ICC-MY was severely reduced in spite of a normal distribution of deep muscular plexus ICC (ICC-DMP). The cecum also exhibited fewer reduced.
Access Restrictions: 限定公開
Rights (production): 〓 2007 国際組織細胞学会
Related Material (DOI): 10.1679/aohc.70.163
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ