Frequent detection of multidrug-resistant pneumonia-causing bacteria in the pneumonia lung tissues of patients with hematological malignancies

• Material Type: 文書・図像類
• Title: Frequent detection of multidrug-resistant pneumonia-causing bacteria in the pneumonia lung tissues of patients with hematological malignancies
• Author/Editor: INAI, Kunihiro; IWASAKI, Hiromichi; NORIKI, Sakon; IKEGAYA, Satoshi; YAMASHITA, Masanori; IMAMURA, Yoshiaki; TAKIMOTO, Nobuo; KATO, Hisataka; UEDA, Takanori; NAIKI, Hironobu
• Author Heading: INAI, Kunihiro; IWASAKI, Hiromichi; NORIKI, Sakon; IKEGAYA, Satoshi; YAMASHITA, Masanori; IMAMURA, Yoshiaki; TAKIMOTO, Nobuo; KATO, Hisataka; UEDA, Takanori; NAIKI, Hironobu
• Publication, Distribution, etc.: Springer
• Publication Date: 2007-10
• Publication Date (W3CDTF): 2007-10
• Periodical title: International journal of hematology
• No. or year of volume/issue: 86 3
• Volume: 86
• Issue: 3
• Pages: 225-232
• Text Language Code: eng
• Subject Heading: Autopsy; Hematological malignancy; Intrapulmonary sputum; Multidrug-resistant bacteria; Pathology; Pneumonia
• Target Audience: 一般
• Note (General): Pneumonia is a critical issue during the agonal phase, and often becomes lethal in the absence of pathogen detection. Autopsy is a powerful tool for analyzing the cause of a patient's death, progression of the disease, and the therapeutic response. However, it is frequently limited to the identification of bacterial strains. To elucidate the pathogenesis during the agonal phase of pneumonia, intrapulmonary sputum was harvested by directly inserting a swab into a resected lung, and the bacterial composition was analyzed using both pathological and microbiological techniques from 15 patients with hematological malignancies, and the results were compared with those from 25 patients with other medical and surgical diseases. Among the 54 bacteria strains isolated from the 40 patients, multidrug-resistant strains were significantly more prevalent in hematological group than in other diseases (16/21 versus 11/33, P = .002). Enterococcus faecium was preferentially isolated from the hematological patients, whereas the methicillin-resistant Staphylococcus aureus was predominantly found in the nonhematological group. Two coagulase-negative Staphylococcus epidermidis strains in hematological diseases may be diagnosed as causative bacteria of pneumonia by both bacterial and pathological techniques. Although the results of this study may not be directly applicable for clinical diagnosis, this approach has a potential to become not only a diagnostic method for bacterial pneumonia, but may be also useful for the analysis of multidrug-resistant pathogens.
• Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20613&item_no=1&attribute_id=22&file_no=1
• Access Restrictions: 限定公開
• Related Material (DOI): 10.1007/BF03006925
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ