Tissue Gene Expression of Renin-Angiotensin System in Human Type 2 Diabetic Nephropathy

Material type: 文書・図像類

Author: KONOSHITA, Tadashiほか

Publisher: American Diabetes Association

Publication date: 2006-04

Material Format: Digital

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Note (General)：: OBJECTIVE—Recent studies have proved that blockade of the renin-angiotensin system (RAS) retards the progression of diabetic nephropathy, whereas hypo...

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Material Type: 文書・図像類
Title: Tissue Gene Expression of Renin-Angiotensin System in Human Type 2 Diabetic Nephropathy
Author/Editor: KONOSHITA, Tadashi
WAKAHARA, Shigeyuki
MIZUNO, Shinichi
MOTOMURA, Makoto
AOYAMA, Chikako
MAKINO, Yasukazu
KAWAI, Yasuyuki
KATO, Norihiko
KONI, Ichiro
MIYAMORI, Isamu
MABUCHI, Hiroshi
Author Heading: KONOSHITA, Tadashi
WAKAHARA, Shigeyuki
MIZUNO, Shinichi
MOTOMURA, Makoto
AOYAMA, Chikako
MAKINO, Yasukazu
KAWAI, Yasuyuki
KATO, Norihiko
KONI, Ichiro
MIYAMORI, Isamu
MABUCHI, Hiroshi
Publication, Distribution, etc.: American Diabetes Association
Publication Date: 2006-04
Publication Date (W3CDTF): 2006-04
Periodical title: Diabetes care
No. or year of volume/issue: 29 4
Volume: 29
Issue: 4
Pages: 848-852
Text Language Code: eng
Target Audience: 一般
Note (General): OBJECTIVE—Recent studies have proved that blockade of the renin-angiotensin system (RAS) retards the progression of diabetic nephropathy, whereas hyporeninemia is known as a typical state in diabetic subjects. The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method. RESEARCH DESIGN AND METHODS—Subjects were 66 nondiabetic and 8 diabetic patients with biopsy-proven renal diseases. The eight diabetic subjects suffered from type 2 diabetes with overt proteinuria. Renal histology revealed typical diffuse or nodular lesions with linear IgG deposit on immunofluorescent staining and thickened basement membrane on electronic microscopy. Total RNA from a small part of the renal cortical biopsy specimens was reverse-transcribed, and the resultant cDNA was amplified for new major components of RAS (i.e., renin, renin receptor, angiotensinogen, ACE, ACE2, angiotensin II type 1 receptor, and angiotensin II type 2 receptor) and measured. RESULTS—Among these components, a significant upregulation was observed in the ACE gene in diabetic renal tissue. CONCLUSIONS—The results suggest that renal tissue RAS might be activated in the respect that ACE gene expression is upregulated in spite of a tendency to low renin expression in type 2 diabetic nephropathy.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20634&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20634&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Related Material (DOI): 10.2337/diacare.29.04.06.dc05-1873
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ