Blockers and barriers to transcription: competing activities?

Material type: 文書・図像類

Author: OKI, Masayaほか

Publisher: Elsevier Science B.V.

Publication date: 2002-06-01

Material Format: Digital

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Note (General)：: In the eukaryotic cell active and inactive genes reside adjacent to one another and are modulated by numerous regulatory elements. Insulator elements ...

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Material Type: 文書・図像類
Title: Blockers and barriers to transcription: competing activities?
Author/Editor: OKI, Masaya
KAMAKAKA, Rohinton T.
Author Heading: OKI, Masaya
KAMAKAKA, Rohinton T.
Publication, Distribution, etc.: Elsevier Science B.V.
Publication Date: 2002-06-01
Publication Date (W3CDTF): 2002-06-01
Periodical title: Current Opinion in Cell Biology
No. or year of volume/issue: 14 3
Volume: 14
Issue: 3
Pages: 299-304
Text Language Code: eng
Target Audience: 一般
Note (General): In the eukaryotic cell active and inactive genes reside adjacent to one another and are modulated by numerous regulatory elements. Insulator elements prevent the misregulation of adjacent genes by restricting the effects of the regulatory elements to specific domains. Enhancer blockers prevent enhancers from inadvertently activating neighboring genes, and recent results suggest that they might function by a conserved mechanism across species. These elements appear to disrupt enhancer-promoter `communications' by interacting with the regulatory elements and sequestering these elements into specific regions of the nucleus thus rendering them non-functional. Barrier elements insulate active genes from neighboring heterochromatin and recent results suggest that they function by specific localized recruitment of acetyltransferases that antagonize the spread of heterochromatin-associated deacetylases, thus preventing the propagation of heterochromatin.
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/S0955-0674(02)00327-7
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ