A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain

Material type: 文書・図像類

Author: Murata, Tetsuhitoほか

Publisher: Cambridge University Press

Publication date: 2007-10

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: We compared the potency of the interaction of three antipsychotic drugs, i.e., chlorpromazine (CPZ), haloperidol (HAL) and sulpiride (SUL), with the p...

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｆｕｋｕｉ　Ａｃａｄｅｍｉｃ　Ｒｅｐｏｓｉｔｏｒｙ
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｆｕｋｕｉ　Ａｃａｄｅｍｉｃ　Ｒｅｐｏｓｉｔｏｒｙ

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain
Author/Editor: Murata, Tetsuhito
Maruoka, Nobuyuki
Omata, Naoto
Takashima, Yasuhiro
Fujibayashi, Yasuhisa
Yonekura, Yoshiharu
Wada, Yuji
Author Heading: Murata, Tetsuhito
Maruoka, Nobuyuki
Omata, Naoto
Takashima, Yasuhiro
Fujibayashi, Yasuhisa
Yonekura, Yoshiharu
Wada, Yuji
Publication, Distribution, etc.: Cambridge University Press
Publication Date: 2007-10
Publication Date (W3CDTF): 2007-10
Periodical title: The international journal of neuropsychopharmacology
No. or year of volume/issue: 10 5
Volume: 10
Issue: 5
Pages: 683-689
ISSN (Periodical Title): ISSN : 1461-1457
Text Language Code: eng
Subject Heading: Plasma membrane
Chlorpromazine
Haloperidol
Sulpiride
Extrapyramidal side effects
Target Audience: 一般
Note (General): We compared the potency of the interaction of three antipsychotic drugs, i.e., chlorpromazine (CPZ), haloperidol (HAL) and sulpiride (SUL), with the plasma membrane in the rat brain. CPZ loading ( 100 M) dose-dependently increased both membrane permeability (assessed as [18F]2-fluoro-2-deoxy-D-glucose-6-phosphate release from brain slices) and membrane fluidity (assessed as the reduction in the plasma membrane anisotropy of 1,6-diphenyl-1,3,5-hexatriene). On the other hand, a higher concentration of HAL (1 mM) was required to observe these effects. However, SUL failed to change membrane permeability and fluidity even at a high concentration (1 mM). These results indicated the following ranking of the potency to interact with the membrane: CPZ > HAL > SUL. The difference among antipsychotic drugs in the potency to interact with the plasma membrane as revealed in the present study may be partly responsible for the difference among the drugs in the probability of inducing extrapyramidal side effects such as parkinsonism and tardive dyskinesia.
Access Restrictions: 限定公開
Related Material (DOI): 10.1017/S1461145706007218
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ