Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Material type: 文書・図像類

Author: KIYOHARA, Takahiroほか

Publisher: Mosby

Publication date: 2006-03

Material Format: Digital

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Note (General)：: Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocar...

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Material Type: 文書・図像類
Title: Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity
Author/Editor: KIYOHARA, Takahiro
KUMAKIRI, Masanobu
KOURABA, Sachio
TOKURIKI, Atsushi
ANSAI, Shinichi
Author Heading: KIYOHARA, Takahiro
KUMAKIRI, Masanobu
KOURABA, Sachio
TOKURIKI, Atsushi
ANSAI, Shinichi
Publication, Distribution, etc.: Mosby
Publication Date: 2006-03
Publication Date (W3CDTF): 2006-03
Periodical title: Journal of the American Academy of Dermatology
No. or year of volume/issue: 54 3
Volume: 54
Issue: 3
Pages: 532-536
Text Language Code: eng
Subject Heading: Signet ring cell carcinoma
Cytokeratin 20
Metastatic adenocarcinoma
Mucin
Target Audience: 一般
Note (General): Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas. It is defined as a diffuse malignant epithelial neoplasia localized in the dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of visceral adenocarcinoma. We present 2 cases of PCSRCC, which involved eyelids and axilla respectively. Despite thorough systemic workup, primary sources could not be demonstrated in either case. The tumor cells are positive for gross cystic disease fluid protein 15 in addition to a variety of glandular markers. Furthermore, both cases were immunostained with cytokeratin 20 (CK20). In conclusion, we report 2 cases of PCSRCC expressing CK20 immunoreactivity. CK20-positive primary cutaneous tumors should include PCSRCC in addition to Merkel cell carcinoma.
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/j.jaad.2005.04.039
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ