Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: Normalization by glyceraldehyde 3-phosphate dehydrogenase

Material type: 文書・図像類

Author: SHIMADA, Ichirohほか

Publisher: SPRINGER

Publication date: 2008-09

Material Format: Digital

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Note (General)：: Under mechanical ventilation with high-inspired oxygen concentration, diffuse alveolar damage (DAD) was found to take place in some patients. To clari...

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Material Type: 文書・図像類
Title: Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: Normalization by glyceraldehyde 3-phosphate dehydrogenase
Author/Editor: SHIMADA, Ichiroh
MATSUI, Kazuhiro
BRINKMANN, Bernd
HOHOFF, Carsten
HIRAGA, Koichi
TABUCHI, Yoshiaki
TAKASAKI, Ichiro
KATO, Ichiro
KAWAGUCHI, Hiroshi
TAKASAWA, Kumi
IIDA, Reiko
TAKIZAWA, Hisao
MATSUKI, Takasumi
Author Heading: SHIMADA, Ichiroh
MATSUI, Kazuhiro
BRINKMANN, Bernd
HOHOFF, Carsten
HIRAGA, Koichi
TABUCHI, Yoshiaki
TAKASAKI, Ichiro
KATO, Ichiro
KAWAGUCHI, Hiroshi
TAKASAWA, Kumi
IIDA, Reiko
TAKIZAWA, Hisao
MATSUKI, Takasumi
Publication, Distribution, etc.: SPRINGER
Publication Date: 2008-09
Publication Date (W3CDTF): 2008-09
Periodical title: INTERNATIONAL JOURNAL OF LEGAL MEDICINE
No. or year of volume/issue: 122 5
Volume: 122
Issue: 5
Pages: 373-383
Text Language Code: eng
Subject Heading: Diffuse alveolar damage
Hyperoxia exposure
Gene expression
Myc
Surfactant-associated protein C
Target Audience: 一般
Note (General): Under mechanical ventilation with high-inspired oxygen concentration, diffuse alveolar damage (DAD) was found to take place in some patients. To clarify the molecular pathophysiology of this condition we investigated the time course of gene expression changes induced by hyperoxia exposure in mouse lung using real-time quantitative polymerase chain reaction (real-time qPCR). Our results normalized by glyceraldehyde 3-phosphate dehydrogenase showed that mRNA levels of cysteine rich protein 61 (CYR61) and connective tissue growth factor (CTGF) were significantly up-regulated, while those of surfactant-associated protein C (SFTPC), cytochrome P450, 2F2 (CYP2F2), Claudin 1, (CLDN1), membrane-associated zonula occludens protein-1 (ZO-1), lysozyme (LYZS), and P lysozyme structural (LZP-S) were significantly down-regulated. Increasing level of mRNAs, each encoding CYR61 and CTGF, suggests a serious risk of fibrosing alveolitis. Decrease in levels of mRNAs for SFTPC, CYP2F2, CLDN1, ZO-1, LYZS, and LZP-S suggests alveolar dysfunction and disruption of the immune system. Moreover we confirmed apoptotic conditions, such as significant up-regulations of mRNA levels in Myc and Galectin-3. Hyperoxic condition probably yielded reactive oxygen species (ROS), which resulted in a malignant cycle of ROS production by Myc overexpression.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19843&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19843&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Related Material (DOI): 10.1007/s00414-008-0226-6
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ