Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder

• Material Type: 文書・図像類
• Title: Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder
• Author/Editor: Okamoto, Y; Kitada, R; Miyahara, M; Kochiyama, T; Naruse, H; Sadato, N; Okazawa, H; Kosaka, H
• Author Heading: Okamoto, Y; Kitada, R; Miyahara, M; Kochiyama, T; Naruse, H; Sadato, N; Okazawa, H; Kosaka, H
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-04-27
• Publication Date (W3CDTF): 2018-04-27
• Periodical title: NeuroImage : Clinical
• No. or year of volume/issue: 19
• Volume: 19
• Pages: 384-395
• ISSN (Periodical Title): ISSN : 2213-1582
• Text Language Code: eng
• Subject Heading: Autism spectrum disorder; Functional magnetic resonance imaging; Visual self-body recognition; Lateral occipito-temporal cortex; Imitation; Inferior parietal lobule; Cerebellum
• Target Audience: 一般
• Note (General): Background:Individuals with autism spectrum disorder (ASD) appear to have a unique awareness of their ownbody, which may be associated with difficulties of gestural interaction. In typically developing (TD) individuals,the perception of body parts is processed in various brain regions. For instance, activation of the lateral occipito-temporal cortex (LOTC) is known to depend on perspective (i.e.,first- or third-person perspective) and identity(i.e., own vs. another person's body). In the present study, we examined how perspective and identity affect brainactivation in individuals with ASD, and how perspective- and identity-dependent brain activation is associatedwith gestural imitation abilities.Methods:Eighteen young adults with ASD and 18 TD individuals participated in an fMRI study in which theparticipants observed their own or another person's hands from thefirst- and third-person perspectives. Weexamined whether the brain activation associated with perspective and identity was altered in individuals withASD. Furthermore, we identified the brain regions the activity of which correlated with gestural imitation dif-ficulties in individuals with ASD.Results:In the TD group, the left LOTC was more strongly activated by viewing a hand from the third-personperspective compared with thefirst-person perspective. This perspective effect in the left LOTC was significantlyattenuated in the ASD group. We also observed significant group differences in the perspective effect in themedial prefrontal cortex (mPFC). Correlation analysis revealed that the perspective effect in the inferior parietallobule (IPL) and cerebellum was associated with the gestural imitation ability in individuals with ASD.Conclusions:Our study suggests that atypical visual self-body recognition in individuals with ASD is associatedwith an altered perspective effect in the LOTC and mPFC, which are thought to be involved in the physical andcore selves, respectively. Furthermore, the gestural imitation difficulty in individuals with ASD might be asso-ciated with the altered activation in the IPL and cerebellum, but not in the LOTC. Thesefindings shed light oncommon and divergent neural mechanisms underlying atypical visual self-body awareness and gestural inter-action in ASD.
• Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=24523&item_no=1&attribute_id=22&file_no=1
• Access Restrictions: 限定公開
• Related Material (DOI): 10.1016/j.nicl.2018.04.030
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ