A case of an infant with extremely low birth weight and hypothyroidism associated with massive cutaneous infantile hemangioma.

Material type: 文書・図像類

Author: Igarashi, A||Hata I||Yuasa M||Okuno T||Ohshima Y

Publisher: De Gruyter

Publication date: 2018-12-19

Material Format: Digital

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Note (General)：: Background Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormon...

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Material Type: 文書・図像類
Title: A case of an infant with extremely low birth weight and hypothyroidism associated with massive cutaneous infantile hemangioma.
Author/Editor: Igarashi, A||Hata I||Yuasa M||Okuno T||Ohshima Y
Author Heading: Igarashi, A||Hata I||Yuasa M||Okuno T||Ohshima Y
Publication, Distribution, etc.: De Gruyter
Publication Date: 2018-12-19
Publication Date (W3CDTF): 2018-12-19
Periodical title: Journal of Pediatric Endocrinology and Metabolism
No. or year of volume/issue: 31 12
Volume: 31
Issue: 12
Pages: 1377-1388
Text Language Code: eng
Subject Heading: cutaneous infantile hemangioma
hypothyroidism
propranolol
Target Audience: 一般
Note (General): Background Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormone inactivating enzyme by hemangioma cells, hypothyroidism has been rarely recognized in infants with cutaneous hemangioma. Case presentation A male infant born at 28 weeks of gestational age with an extremely low birth weight (775 g) developed a massive cutaneous hemangioma on his neck and severe abdominal distension. Imaging examinations detected a small mass lesion in the brain but no hepatic hemangioma. Laboratory findings at the age of 26 days revealed hypothyroidism. Although high-dose levothyroxine therapy failed to normalize the thyroid function, hypothyroidism improved and cutaneous hemangioma regressed after initiating propranolol therapy. Conclusions Our findings suggest that consumptive hypothyroidism should be considered as a critical comorbidity in patients with massive cutaneous IH. Propranolol therapy can effectively normalize thyroid function and cause hemangioma regression.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=24541&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=24541&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Related Material (DOI): 10.1515/jpem-2018-0369
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ