The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria.

• Material Type: 文書・図像類
• Title: The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria.
• Author/Editor: Yuming, Wang; Jiliang, Fang; Ping, Song; Yan, Bao; Wenwen, Song; Jiao, Liu; Courtney, Lang; Kristen, Jorgenson; Minyoung, Jung; Dong, Shen; Shasha, Li; Ruirui, Sun; Xu, Ding; Jiao, Yang; Xiao, Meng; Ning, Wang; Zhifang, Yan; Yuhe, Yan; Qian, Kong; Ying, Dong; Fangyuan, Cui; Yiheng, Tu; Bingnan, Cui; Jian, Kong
• Author Heading: Yuming, Wang; Jiliang, Fang; Ping, Song; Yan, Bao; Wenwen, Song; Jiao, Liu; Courtney, Lang; Kristen, Jorgenson; Minyoung, Jung; Dong, Shen; Shasha, Li; Ruirui, Sun; Xu, Ding; Jiao, Yang; Xiao, Meng; Ning, Wang; Zhifang, Yan; Yuhe, Yan; Qian, Kong; Ying, Dong; Fangyuan, Cui; Yiheng, Tu; Bingnan, Cui; Jian, Kong
• Publication, Distribution, etc.: Springer Verlag (Germany)
• Publication Date: 2018-10-31
• Publication Date (W3CDTF): 2018-10-31
• Periodical title: Cerebellum
• No. or year of volume/issue: 5
• Volume: 5
• Pages: 507-516
• ISSN (Periodical Title): ISSN : 1473-4222; ISSN : 1473-4230
• Text Language Code: eng
• Subject Heading: Resting-state functional magnetic resonance imaging (rs-fMRI); Itch; Chronic spontaneous urticaria; Cerebellum; Reward; Sensorimotor
• Target Audience: 一般
• Note (General): Chronic spontaneous urticaria (CSU) is a common itchy skin disease. Despite its prevalence, the neuropathology of CSU is uncertain. In this study, we explored resting state functional connectivity (rs-FC) changes in CSU, as well as how the symptom changes following intervention can modulate rs-FC. Forty patients and 40 healthy controls (HCs) were recruited. Following an intervention, 32 patients participated in a second scan approximately 6 weeks after the first scan. Compared with healthy controls, CSU subjects exhibited higher regional homogeneity (ReHo) values in the cerebellum, which were positively associated with urticaria activity scores over 7 days (UAS7) at baseline. After an intervention accompanied with clinical improvement, we found that ReHo values decreased at the cerebellum and increased at the bilateral primary somatosensory cortex (SI)/primary motor cortex (MI)/supplementary motor area (SMA). Using the cerebellum as a seed, CSU subjects exhibited increased rs-FC with reward regions when compared with HCs and exhibited decreased rs-FC at the right orbitofrontal cortex and right sensorimotor region following the intervention. The improvement rate values were positively associated with reduced rs-FC values in the two regions. Using the cluster of SI/MI/SMA as a seed, CSU patients exhibited decreased rs-FC with the left putamen, caudate, accumbens, and thalamus following the intervention. These results demonstrate the altered cerebellar activity and cerebellum-reward-sensorimotor loops in CSU.
• Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=24602&item_no=1&attribute_id=22&file_no=1
• Access Restrictions: 限定公開
• Related Material (DOI): 10.1007/s12311-018-0933-6
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ