CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

• Material Type: 文書・図像類
• Title: CD38, CD157, and RAGE as Molecular Determinants for Social Behavior
• Author/Editor: Tanaka, Yukie; Higashida, Haruhiro; Hashii, Minako; Matsukawa, Shigeru; Higuchi, Yoshihiro; Gabata, Ryosuke; Tsubomoto, Makoto; Seishima, Noriko; Teramachi, Mitsuyo; Kamijima, Taiki; Hattori, Tsuyoshi; Hori, Osamu; Tsuji, Chiharu; Cherepanov, Stanislav M.; Shabalova, Anna A.; Gerasimenko, Maria; Minami, Kana; Yokoyama, Shigeru; Munesue, Sei-ichi; Harashima, Ai
• Author Heading: Tanaka, Yukie; Higashida, Haruhiro; Hashii, Minako; Matsukawa, Shigeru; Higuchi, Yoshihiro; Gabata, Ryosuke; Tsubomoto, Makoto; Seishima, Noriko; Teramachi, Mitsuyo; Kamijima, Taiki; Hattori, Tsuyoshi; Hori, Osamu; Tsuji, Chiharu; Cherepanov, Stanislav M.; Shabalova, Anna A.; Gerasimenko, Maria; Minami, Kana; Yokoyama, Shigeru; Munesue, Sei-ichi; Harashima, Ai
• Publication Date: 2019-12
• Publication Date (W3CDTF): 2019-12
• Periodical title: Cells
• No. or year of volume/issue: 9 1
• Volume: 9
• Issue: 1
• Pages: 62-1-16
• ISSN (Periodical Title): ISSN : 2073-4409
• Text Language Code: eng
• Subject Heading: ADVANCED glycation end-products; SINGLE nucleotide polymorphisms; AUTISM spectrum disorders; PARKINSON'S disease; BLOOD-brain barrier; NERVOUS system; cyclic adp-ribose (cadpr); social memory; oxytocin transporter; QH301-705.5
• Target Audience: 一般
• Note (General): Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-nucleotide polymorphisms of the CD38 and CD157/BST1 genes are associated with multiple neurological and psychiatric conditions, including autism spectrum disorder, Parkinson's disease, and schizophrenia. In addition, both antigens are related to infectious and immunoregulational processes. The most important clues to demonstrate how these molecules play a role in the brain are oxytocin (OT) and the OT system. OT is axo-dendritically secreted into the brain from OT-containing neurons and causes activation of OT receptors mainly on hypothalamic neurons. Here, we overview the CD38/CD157-dependent OT release mechanism as the initiation step for social behavior. The receptor for advanced glycation end-products (RAGE) is a newly identified molecule as an OT binding protein and serves as a transporter of OT to the brain, crossing over the blood–brain barrier, resulting in the regulation of brain OT levels. We point out new roles of CD38 and CD157 during neuronal development and aging in relation to nicotinamide adenine dinucleotide+ levels in embryonic and adult nervous systems. Finally, we discuss how CD38, CD157, and RAGE are crucial for social recognition and behavior in daily life. [ABSTRACT FROM AUTHOR]
• Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=24834&item_no=1&attribute_id=22&file_no=1
• Access Restrictions: 限定公開
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• Related Material (DOI): 10.3390/cells9010062
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ