Balancing specificity, sensitivity, and speed of ligand discrimination by zero-order ultraspecificity

Material type: 文書・図像類

Author: Kajita, Masashi K.ほか

Publisher: American Physical Society

Publication date: 2017-07-14

Material Format: Digital

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Note (General)：: Specific interactions between receptors and their target ligands in the presence of nontarget ligands are crucial for biological processes such as T c...

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Material Type: 文書・図像類
Title: Balancing specificity, sensitivity, and speed of ligand discrimination by zero-order ultraspecificity
Author/Editor: Kajita, Masashi K.
Aihara, Kazuyuki
Kobayashi, Tetsuya J.
Author Heading: Kajita, Masashi K.
Aihara, Kazuyuki
Kobayashi, Tetsuya J.
Publication, Distribution, etc.: American Physical Society
Publication Date: 2017-07-14
Publication Date (W3CDTF): 2017-07-14
Periodical title: Physical Review E
No. or year of volume/issue: 96 1
Volume: 96
Issue: 1
Pages: 012405-1-14
ISSN (Periodical Title): ISSN : 2470-0045
Text Language Code: eng
Subject Heading: Quantitative Biology - Molecular Networks
Target Audience: 一般
Note (General): Specific interactions between receptors and their target ligands in the presence of nontarget ligands are crucial for biological processes such as T cell ligand discrimination. To discriminate between the target and nontarget ligands, cells have to increase specificity to the target ligands by amplifying the small differences in affinity among ligands. In addition, sensitivity to the ligand concentration and quick discrimination are also important to detect low amounts of target ligands and facilitate fast cellular decision making after ligand recognition. In this work we propose a mechanism for nonlinear specificity amplification (ultraspecificity) based on zero-order saturating reactions, which was originally proposed to explain nonlinear sensitivity amplification (ultrasensitivity) to the ligand concentration. In contrast to the previously proposed proofreading mechanisms that amplify the specificity by a multistep reaction, our model can produce an optimal balance of specificity, sensitivity, and quick discrimination. Furthermore, we show that a model for insensitivity to a large number of nontarget ligands can be naturally derived from a model with the zero-order ultraspecificity. The zero-order ultraspecificity, therefore, may provide an alternative way to understand ligand discrimination from the viewpoint of nonlinear properties in biochemical reactions.
Access Restrictions: 限定公開
Rights (production): (c) 2020 American Physical Society.
Related Material (DOI): 10.1103/PhysRevE.96.012405
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ