GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice

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Author: Murata, Koshi Murataほか

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Publication date: 2019-05-09

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Note (General)：: Olfaction guides goal-directed behaviours including feeding. To investigate how central olfactory neural circuits control feeding behaviour in mice, w...

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Material Type: 文書・図像類
Title: GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice
Author/Editor: Murata, Koshi Murata
Kinoshita, Tomoki
Fukazawa, Yugo
Kobayashi, Kenta
Kobayashi, Kazuto
Miyamichi, Kazunari
Okuno, Hiroyuki
Bito, Haruhiko
Sakurai, Yoshio
Yamaguchi, Masahiro
Mori, Kensaku
Manabe, Hiroyuki
Author Heading: Murata, Koshi Murata
Kinoshita, Tomoki
Fukazawa, Yugo
Kobayashi, Kenta
Kobayashi, Kazuto
Miyamichi, Kazunari
Okuno, Hiroyuki
Bito, Haruhiko
Sakurai, Yoshio
Yamaguchi, Masahiro
Mori, Kensaku
Manabe, Hiroyuki
Publication Date: 2019-05-09
Publication Date (W3CDTF): 2019-05-09
Periodical title: Scientific Reports
No. or year of volume/issue: 9
Volume: 9
Pages: 1-14
ISSN (Periodical Title): ISSN : 2045-2322
Text Language Code: eng
Subject Heading: Medicine
Science
Target Audience: 一般
Note (General): Olfaction guides goal-directed behaviours including feeding. To investigate how central olfactory neural circuits control feeding behaviour in mice, we performed retrograde tracing from the lateral hypothalamus (LH), an important feeding centre. We observed a cluster of retrogradely labelled cells distributed in the posteroventral region of the olfactory peduncle. Histochemical analyses revealed that the majority of these retrogradely labelled projection neurons expressed glutamic acid decarboxylase 65/67 (GAD65/67), but not vesicular glutamate transporter 1 (VGluT1). We named this region containing GABAergic projection neurons the ventral olfactory nucleus (VON) to differentiate it from the conventional olfactory peduncle. VON neurons were less immunoreactive for DARPP-32, a striatal neuron marker, compared to neurons in the olfactory tubercle and nucleus accumbens, which distinguished the VON from the ventral striatum. Fluorescent labelling confirmed putative synaptic contacts between VON neurons and olfactory bulb projection neurons. Rabies-virus-mediated trans-synaptic labelling revealed that VON neurons received synaptic inputs from the olfactory bulb, other olfactory cortices, horizontal limb of the diagonal band, and prefrontal cortex. Collectively, these results identify novel GABAergic projection neurons in the olfactory cortex that may integrate olfactory sensory and top-down inputs and send inhibitory output to the LH, which may modulate odour-guided LH-related behaviours.
Access Restrictions: 限定公開
Rights (production): This article is licensed under a Creative Commons Attribution 4.0 International License.
Related Material (DOI): 10.1038/s41598-019-43580-1
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ