Nanofiber-Mâché Hollow BallMimicking the Three-Dimensional Structure of a Cyst

Material type: 文書・図像類

Author: Huang, Wan-Yingほか

Publisher: MDPI

Publication date: 2021-07-11

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Note (General)：: The occasional malignant transformation of intracranial epidermoid cysts into squamous cell carcinomas remains poorly understood; the development of a...

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Material Type: 文書・図像類
Title: Nanofiber-Mâché Hollow BallMimicking the Three-Dimensional Structure of a Cyst
Author/Editor: Huang, Wan-Ying
Hashimoto, Norichika
Kitai, Ryuhei
Suye, Shin-ichiro
Fujita, Satoshi
Author Heading: Huang, Wan-Ying
Hashimoto, Norichika
Kitai, Ryuhei
Suye, Shin-ichiro
Fujita, Satoshi
Publication, Distribution, etc.: MDPI
Publication Date: 2021-07-11
Publication Date (W3CDTF): 2021-07-11
Periodical title: Polymers
No. or year of volume/issue: 2021 13
Volume: 2021
Issue: 13
Pages: 2273-
Text Language Code: eng
Subject Heading: electrospinning
nanofiber
hollow ball
alginate
tissue engineering
3D structure
Target Audience: 一般
Note (General): The occasional malignant transformation of intracranial epidermoid cysts into squamous cell carcinomas remains poorly understood; the development of an in vitro cyst model is urgently needed. For this purpose, we designed a hollow nanofiber sphere, the “nanofiber-mâché ball.” This hollow structure was fabricated by electrospinning nanofiber onto alginate hydrogel beads followed by dissolving the beads. A ball with approximately 230 mm3 inner volume provided a fibrous geometry mimicking the topography of the extracellular matrix. Two ducts located on opposite sides provided a route to exchange nutrients and waste. This resulted in a concentration gradient that induced oriented migration, in which seeded cells adhered randomly to the inner surface, formed a highly oriented structure, and then secreted a dense web of collagen fibrils. Circumferentially aligned fibers on the internal interface between the duct and hollow ball inhibited cells from migrating out of the interior, similar to a fish bottle trap. This structure helped to form an adepithelial layer on the inner surface. The novel nanofiber-mâché technique, using a millimeter-sized hollow fibrous scaffold, is excellently suited to investigating cyst physiology.
source:https://www.mdpi.com/2073-4360/13/14/2273
Access Restrictions: 限定公開
Related Material (DOI): 10.3390/polym13142273
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ