Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice

Material type: 文書・図像類

Author: Tanaka, Kimieほか

Publisher: The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases

Publication date: 2020

Material Format: Digital

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Note (General)：: Aim: Synthetic vascular grafts are widely used in surgical revascularization, mainly for medium- to large-sized vessels. However, synthetic grafts sma...

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Material Type: 文書・図像類
Title: Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice
Author/Editor: Tanaka, Kimie
Fukuda, Daiju
Higashikuni, Yasutomi
Hirata, Yoichiro
Komuro, Issei
Saotome, Toshiki
Yamashita, Yoshihiro
Asakura, Tetsuo
Sata, Masataka
Author Heading: Tanaka, Kimie
Fukuda, Daiju
Higashikuni, Yasutomi
Hirata, Yoichiro
Komuro, Issei
Saotome, Toshiki
Yamashita, Yoshihiro
Asakura, Tetsuo
Sata, Masataka
Publication, Distribution, etc.: The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases
Publication Date: 2020
Publication Date (W3CDTF): 2020
Alternative Title: Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice
Periodical title: Journal of Atherosclerosis and Thrombosis
No. or year of volume/issue: 27
Volume: 27
Pages: 1299-1309
ISSN (Periodical Title): ISSN : 1880-3873
ISSN : 1340-3478
Text Language Code: eng
Subject Heading: Mouse
Fibroin
Vascular graft
Smooth muscle cells
Endothelial cells
Target Audience: 一般
Note (General): Aim: Synthetic vascular grafts are widely used in surgical revascularization, mainly for medium- to large-sized vessels. However, synthetic grafts smaller than 6 mm in diameter are associated with a high incidence of thrombosis. In this study, we evaluated silk fibroin, a major protein of silk, with high biocompatibility and biodegradability, as a useful material for extremely-small-diameter vascular grafts.Methods: A small-sized (0.9 mm inner diameter) graft was braided from a silk fibroin thread. The right carotid arteries of 8- to 14-week-old male C57BL/6 mice were cut at the midpoint, and fibroin grafts (5- to 7-mm in length) were transplanted using a cuff technique with polyimide cuffs. The grafts were harvested at different time points and analyzed histologically.Results: CD31＋ endothelial cells had already started to proliferate at 2 weeks after implantation. At 4 weeks, neointima had formed with α-smooth muscle actin+ cells, and the luminal surface was covered with CD31＋ endothelial cells. Mac3＋ macrophages were accumulated in the grafts. Graft patency was confirmed at up to 6months after implantation.Conclusion: This mouse model of arterial graft implantation enables us to analyze the remodeling process and biocompatibility of extremely-small-diameter vascular grafts. Biodegradable silk fibroin might be applicable for further researches using genetically modified mice.
source:https://www.jstage.jst.go.jp/article/jat/27/12/27_52720/_article
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=29068&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=29068&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-SA
Related Material (DOI): 10.5551/jat.52720
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ