Molecular Analysis of Carbon Ion-Induced Mutations in DNA Repair-Deficient Strains of Saccharomyces cerevisiae

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Author: Matuo , Youichirouほか

Publisher: MDPI

Publication date: 2019-07-02

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Note (General)：: Mutations caused by ion beams have been well-studied in plants, including ornamental flowers, rice, and algae. It has been shown that ion beams have s...

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Material Type: 文書・図像類
Title: Molecular Analysis of Carbon Ion-Induced Mutations in DNA Repair-Deficient Strains of Saccharomyces cerevisiae
Author/Editor: Matuo , Youichirou
Izumi , Yoshinobu
Sakamoto, Ayako N
Hase , Yoshihiro
Satoh , Katsuya
Shimizu , Kikuo
Author Heading: Matuo , Youichirou
Izumi , Yoshinobu
Sakamoto, Ayako N
Hase , Yoshihiro
Satoh , Katsuya
Shimizu , Kikuo
Publication, Distribution, etc.: MDPI
Publication Date: 2019-07-02
Publication Date (W3CDTF): 2019-07-02
Alternative Title: Molecular Analysis of Carbon Ion-Induced Mutations in DNA Repair-Deficient Strains of Saccharomyces cerevisiae
Periodical title: Quantum Beam Science
No. or year of volume/issue: 3 3
Volume: 3
Issue: 3
Pages: 4-
ISSN (Periodical Title): ISSN : 2412-382X
Text Language Code: eng
Subject Heading: carbon ion beam
mutation
S. cerevisiae
8-oxodG
high LET
Target Audience: 一般
Note (General): Mutations caused by ion beams have been well-studied in plants, including ornamental flowers, rice, and algae. It has been shown that ion beams have several significantly interesting features, such as a high biological effect and unique mutation spectrum, which is in contrast to low linear energy transfer (LET) radiation such as gamma rays. In this study, the effects of double strand breaks and 8-oxo-2′-deoxyguanosine (8-oxodG) caused by ion-beam irradiation were examined. We irradiated repair-gene-inactive strains rad52, ogg1, and msh2 using carbon ion beams, analyzed the lethality and mutagenicity, and characterized the mutations. High-LET carbon ion-beam radiation was found to cause oxidative base damage, such as 8-oxodG, which can lead to mutations. The present observations suggested that nucleotide incorporation of oxidative damage gave only a limited effect on cell viability and genome fidelity. The ion-beam mutations occurred predominantly in 5′-ACA-3′ sequences, and we detected a hotspot at around +79 to +98 in URA3 in wild-type and mutant lines, suggesting the presence of a mutation-susceptible region. View Full-Text
source:https://www.mdpi.com/2412-382X/3/3/14
Access Restrictions: 限定公開
Rights (production): cc-by 4.0
Related Material (DOI): 10.3390/qubs3030014
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ