腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた

• Material Type: 博士論文
• Title: 腫瘍マウスモデルにおいてプロリル水酸化酵素阻害剤による腫瘍血管の正常化は化学療法に対する感受性を回復させた
• Author/Editor: 小山, 哲史; Koyama, Satoshi
• Author Heading: 小山, 哲史; Koyama, Satoshi
• Alternative Title: Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model
• Degree grantor/type: 鳥取大学
• Date Granted: 2017-09-30
• Dissertation Number: 甲第866号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Blood vessels are important tissue structures that deliver oxygen and nutrition. In tumour tissue, abnormal blood vessels, which are hyperpermeable and immature, are often formed; these tissues also have irregular vascularisation and intravasation. This situation leads to hypoperfusion in tumour tissue along with low oxygen and nutrition depletion; this is also called the tumour microenvironment and is characterised by hypoxia, depleted nutrition, low pH and high interstitial pressure. This environment induces resistance to anticancer drugs, which causes an increase in anticancer drug doses, leading to increased side effects. We hypothesised that normalised tumour blood vessels would improve tumour tissue perfusion, resupply nutrition and re-oxygenate the tumour tissue. Chemotherapy would then be more effective and cause a decrease in anticancer drug doses. Here we report a neovascularisation-inducing drug that improved tumour vascular abnormalities, such as low blood flow, blood leakage and abnormal vessel structure. These results could lead to not only an increased chemo-sensitivity and tissue-drug distribution but also an up-regulated efficiency for cancer chemotherapy. This suggests that tumour blood vessel normalisation therapy accompanied by angiogenesis may be a novel strategy for cancer therapy.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the ma
• Related Material: Koyama, S. et al. Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model. Sci. Rep. 7, 45621; doi: 10.1038/srep45621 (2017).; URI; http://www.nature.com/articles/srep45621
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鳥取大学 : 鳥取大学研究成果リポジトリ

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