特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究

• Material Type: 博士論文
• Title: 特発性間質性肺炎の急性増悪の治療のための白血球除去療法 : パイロット研究
• Author/Editor: 山本, 章祐
• Author Heading: 山本, 章祐
• Alternative Title: Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias : a pilot study
• Degree grantor/type: 鳥取大学
• Date Granted: 2018-03-01
• Dissertation Number: 甲第876号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Objective: Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous diffuse parenchymal lung disorders of unknown etiology. An acute exacerbation (AE) is an acute respiratory deterioration that occurs in IIPs. The prognosis of AE of IIPs (AE-IIPs) is extremely severe; however, no established therapies exist. We aimed to evaluate the efficacy of leukocytapheresis (LCAP) to treat patients with AE-IIPs. Patients and Methods: Six chronic IIPs patients who developed AE were enrolled in this study. We performed LCAP on days 2, 3, 9 and 10 in all six patients. All patients were also treated with high-dose corticosteroids and a continuous administration of low-molecular-weight heparin. We observed 30-day survival after the diagnosis of AE to evaluate the efficacy of LCAP. We also assessed oxygenation, high-resolution computed tomography (HRCT) findings, and certain chemical mediators in the peripheral blood. Results: Five of six patients survived more than 30 days. One patient died of progressive respiratory failure. Oxygenation and HRCT findings tended to improve in all survivors. The serum levels of lactate dehydrogenase, high mobility group box-1, and interleukin-18 were significantly decreased statistically post-LCAP. No severe adverse events occurred. Conclusion: We suggest that LCAP is a safe and effective therapy for treating patients with AE-IIPs. J. Med. Invest. 64: 110-116, February, 2017
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): 注があるものを除き、この著作物は日本国著作権法により保護されています。
• Related Material: This research was published by The Journal of Medical Investigation: YAMAMOTO, Akihiro, et al. Leukocytapheresis for the treatment of acute exacerbation of idiopathic interstitial pneumonias: a pilot study. The Journal of Medical Investigation, 2017, 64.1; URI; https://www.jstage.jst.go.jp/article/jmi/64/1.2/64_110/_article
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鳥取大学 : 鳥取大学研究成果リポジトリ

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