Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population

• Material Type: 博士論文
• Title: Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population
• Author/Editor: Yamaguchi, Miwa; Arisawa, Kokichi; Uemura, Hirokazu; Katuura-Kamano, Sakurako; Takami, Hidenobu; Sawachika, Fusakazu; Nakamoto, Mariko; Juta, Tomoya; Toda, Eisaku; Mori, Kei; Hasegawa, Manabu; Tanto, Masaharu; Shima, Masayuki; Sumiyoshi, Yoshio; Kodama, Kazunori; Suzuki, Takaichiro; Nagai, Masaki; Satoh, Hiroshi
• Author Heading: Yamaguchi, Miwa; Arisawa, Kokichi; Uemura, Hirokazu; Katuura-Kamano, Sakurako; Takami, Hidenobu; Sawachika, Fusakazu; Nakamoto, Mariko; Juta, Tomoya; Toda, Eisaku; Mori, Kei; Hasegawa, Manabu; Tanto, Masaharu; Shima, Masayuki; Sumiyoshi, Yoshio; Kodama, Kazunori; Suzuki, Takaichiro; Nagai, Masaki; Satoh, Hiroshi
• Publication, Distribution, etc.: Japan Society for Occupational Health|Wiley
• Publication Date: 2013-04-09
• Publication Date (W3CDTF): 2013-04-09
• Alternative Title: 日本人における魚介類摂取頻度、血清肝機能酵素とPFOS、PFOAの血液中濃度; Seafood, Serum Liver Enzymes, PFOS and PFOA in Blood
• Periodical title: Journal of Occupational Health
• No. or year of volume/issue: 55 3
• Volume: 55
• Issue: 3
• Pages: 184-194
• ISSN (Periodical Title): ISSN : 1348-9585; ISSN : 1341-9145
• Degree grantor/type: 徳島大学
• Date Granted: 2013-05-23
• Dissertation Number: 甲第2617号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Blood; Fish intake; Perfluorooctanesulfonate (PFOS); Perfluorooctanoate (PFOA); Serum liver enzymes
• Target Audience: 一般
• Note (General): Objective: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ-GTP, GOT, and GPT) and ω-3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω-3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.
• Format (IMT): application/pdf
• Source: http://repo.lib.tokushima-u.ac.jp/files/public/10/105887/20170929150145736227/LID201308190002.pdf （fulltext）; http://repo.lib.tokushima-u.ac.jp/files/public/10/105887/20170929150145736227/LID201308190002.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1539/joh.12-0264-OA
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ