The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

• Material Type: 博士論文
• Title: The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
• Author/Editor: Asano, Jin; Nakano, Ayako; Oda, Asuka; Amou, Hiroe; Hiasa, Masahiro; Takeuchi, Kyoko; Miki, Hirokazu; Nakamura, Shingen; Harada, Takeshi; Fujii, Shiro; Kagawa, Kumiko; Endo, Itsuro; Yata, Kenichiro; Sakai, Akira; Ozaki, Shuji; Matsumoto, Toshio; Abe, Masahiro
• Author Heading: Asano, Jin; Nakano, Ayako; Oda, Asuka; Amou, Hiroe; Hiasa, Masahiro; Takeuchi, Kyoko; Miki, Hirokazu; Nakamura, Shingen; Harada, Takeshi; Fujii, Shiro; Kagawa, Kumiko; Endo, Itsuro; Yata, Kenichiro; Sakai, Akira; Ozaki, Shuji; Matsumoto, Toshio; Abe, Masahiro
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2011-04-08
• Publication Date (W3CDTF): 2011-04-08
• Alternative Title: セリンスレオニンキナーゼPim-2は骨髄腫における新規抗アポトーシス媒介因子である; Pim-2 in myeloma cells
• Periodical title: Leukemia
• No. or year of volume/issue: 25 7
• Volume: 25
• Issue: 7
• Pages: 1182-1188
• ISSN (Periodical Title): ISSN : 0887-6924; ISSN : 1476-5551
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-19
• Dissertation Number: 甲第2741号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Pim-2; myeloma; bone marrow stromal cell; osteoclast; IL-6
• Target Audience: 一般
• Note (General): Bone marrow stromal cells (BMSCs) and osteoclasts (OCs) confer multiple myeloma (MM) cell survival through elaborating factors. We demonstrate herein that IL-6 and TNF family cytokines, TNFα, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in MM cells. BMSCs and OCs upregulate Pim-2 expression in MM cells largely via the IL-6/STAT3 and NF-ｋB pathway, respectively. Pim-2 short interfering RNA reduces MM cell viability in cocultures with BMSCs or OCs. Thus, upregulation of Pim-2 appears to be a novel anti-apoptotic mechanism for MM cell survival. Interestingly, the mammalian target of rapamycin inhibitor rapamycin further suppresses the MM cell viability in combination with the Pim-2 silencing. The Pim inhibitor (Z)-5-(4-propoxybenzylidene) thiazolidine-2, 4-dione and the PI3K inhibitor LY294002 cooperatively enhance MM cell death. The Pim inhibitor suppresses 4E-BP1 phosphorylation along with the reduction of Mcl-1 and c-Myc. Pim-2 may therefore become a new target for MM treatment.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/leu.2011.60
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/10/106134/20170929145200563523/LID201405131005.pdf fulltext

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