Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia

• Material Type: 博士論文
• Title: Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia
• Author/Editor: Nishi, Akira; Numata, Shusuke; Tajima, Atsushi; Kinoshita, Makoto; Kikuchi, Kumiko; Shimodera, Shinji; Tomotake, Masahito; Ohi, Kazutaka; Hashimoto, Ryota; Imoto, Issei; Takeda, Masatoshi; Ohmori, Tetsuro
• Author Heading: Nishi, Akira; Numata, Shusuke; Tajima, Atsushi; Kinoshita, Makoto; Kikuchi, Kumiko; Shimodera, Shinji; Tomotake, Masahito; Ohi, Kazutaka; Hashimoto, Ryota; Imoto, Issei; Takeda, Masatoshi; Ohmori, Tetsuro
• Publication, Distribution, etc.: Maryland Psychiatric Research Center|Oxford University Press
• Publication Date: 2014-02-17
• Publication Date (W3CDTF): 2014-02-17
• Alternative Title: 統合失調症における性差を考慮した血中ホモシステイン濃度ならびにMTHFR遺伝子C677T多型の遺伝子関連研究のメタ解析; MTHFR, Homocysteine, and Schizophrenia
• Periodical title: Schizophrenia Bulletin
• No. or year of volume/issue: 40 5
• Volume: 40
• Issue: 5
• Pages: 1154-1163
• ISSN (Periodical Title): ISSN : 1745-1701; ISSN : 0586-7614
• Degree grantor/type: 徳島大学
• Date Granted: 2015-03-23
• Dissertation Number: 甲第2805号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: mendelian randomization; SNP; Japanese; plasma homocysteine
• Target Audience: 一般
• Note (General): Previous studies suggest that elevated blood homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for schizophrenia. However, the effects of gender and MTHFR C677T genotypes on blood homocysteine levels in schizophrenia have not been consistent. We first investigated whether plasma total homocysteine levels were higher in patients with schizophrenia than in controls with stratification by gender and by the MTHFR C677T genotypes in a large cohort (N = 1379). Second, we conducted a meta-analysis of association studies between blood homocysteine levels and schizophrenia separately by gender (N = 4714). Third, we performed a case-control association study between the MTHFR C677T polymorphism and schizophrenia (N = 4998) and conducted a meta-analysis of genetic association studies based on Japanese subjects (N = 10 378). Finally, we assessed the effect of plasma total homocysteine levels on schizophrenia by a mendelian randomization approach. The ANCOVA after adjustment for age demonstrated a significant effect of diagnosis on the plasma total homocysteine levels in all strata, and the subsequent meta-analysis for gender demonstrated elevated blood homocysteine levels in both male and female patients with schizophrenia although antipsychotic medication might influence the outcome. The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia. The mendelian randomization analysis in the Japanese populations yielded an OR of 1.15 for schizophrenia per 1-SD increase in plasma total homocysteine. Our study suggests that increased plasma total homocysteine levels may be associated with an increased risk of schizophrenia.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [e-mail]
• Related Material (DOI): 10.1093/schbul/sbt154
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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