The Ceramics Radiating Far Infrared Ray Energy (Rhyolite) Promote the Formation of Bone

• Material Type: 博士論文
• Title: The Ceramics Radiating Far Infrared Ray Energy (Rhyolite) Promote the Formation of Bone
• Author/Editor: Dolgorsuren, Aldartsogt; Yamashita, Kikuji; Dalkhsuren, Shine-Od; Sumida, Kaori; Seki, Shinichiro; Kitamura, Seiichiro
• Author Heading: Dolgorsuren, Aldartsogt; Yamashita, Kikuji; Dalkhsuren, Shine-Od; Sumida, Kaori; Seki, Shinichiro; Kitamura, Seiichiro
• Publication, Distribution, etc.: THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
• Publication Date: 2014-10-21
• Publication Date (W3CDTF): 2014-10-21
• Alternative Title: 遠赤外線エネルギーを放射するセラミックス（流紋岩）は骨形成を促進する; FIR Ceramics Promote the Formation of Bone
• Periodical title: Journal of Hard Tissue Biology
• No. or year of volume/issue: 23 4
• Volume: 23
• Issue: 4
• Pages: 423-434
• ISSN (Periodical Title): ISSN : 1880-828X; ISSN : 1341-7649
• Degree grantor/type: 徳島大学
• Date Granted: 2015-03-23
• Dissertation Number: 甲第2808号
• Degree Type: 博士（学術）
• Text Language Code: eng
• Subject Heading: Bone formation; Far-infrared ray; Osteoblast
• Target Audience: 一般
• Note (General): Far infrared ray (FIR) energy radiated by the natural ceramics (Rhyolite) cooled FIR ceramics activates water molecules and blood circulation to stimulate skin and other tissues. The aim of our study is to make clear whether the FIR ceramics radiating FIR energy affect or not on the new bone formation in vivo and in vitro. Methods: MC3T3-E1 cells were cultured in FIR CO2 incubator. The cell proliferation and the gene expression were analyzed by using WST-8 assay kit, RT-PCR and micro array analysis. The enzyme activities were analyzed by using the apiRZYM kit. Furthermore, titanium and natural FIR ceramics compounds were implanted under the periosteium of rat skull bone by injection method. Four weeks later, the samples were examined by the light microscope and micro CT analyses. Results: Proliferation of MC3T3-E1 cell was and DNA concentrations were inhibited by FIR energy radiation. The ALP activities were accelerated and the area of calcification nodules increased on 4 weeks. The RT-PCR data showed that the gene Runx2, Osterix, BSP, OCN, Col1a1 and OPN expression of MC3T3-E1 osteoblast like cells was activated. Bone mineral density (BMD mg/cm²) of implanted sites of T50-F50, T25-F75 and F100 groups was significantly enhanced after 4 weeks compared with control groups. This data shows FIR energy radiation by the natural FIR ceramics promoted bone-forming activity of osteoblasts. Significance: This study suggested that new bioactive ceramics such us natural FIR ceramics was useful for some clinically applications to repair bone defects for example of dental implant surgery.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2014 The Hard Tissue Biology Network Association
• Related Material (DOI): 10.2485/jhtb.23.423
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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